Fathima Rehman

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Culture and drug susceptibility testing results of 2816 tuberculosis (TB) patients from across India who had failed repeated treatments from 2001 to 2004 were retrospectively analysed at the Tuberculosis Research Centre, Chennai. Of 1498 (53%) identified as having multidrug-resistant TB (MDR-TB), 671 (44.8%) were resistant to > or =1 second-line drugs(More)
A direct sensitivity test for rifampicin has been standardised for early detection of resistance for the mycobacterium tuberculosis smear positive sputum samples. Indirect sensitivity tests set up from primary cultures of the same samples served as controls. The direct test showed 95 per cent agreement with the standard indirect test and as such 74 per cent(More)
BACKGROUND & OBJECTIVE Three categories of prognostic markers are best documented as having significance in relation to prognosis of HIV infection. These include HIV viral load, CD4 T-cell levels and plasma levels of soluble markers of immune activation. The plasma activation markers, like neopterin, tumor necrosis factor alpha (TNF-alpha), interleukins(More)
This study examines the acceptability of condoms to men from Chennai, South India. A sample of 150 male respondents who, in the main, had at least one risky sexual experience with a commercial sex worker or multiple partners was interviewed. The respondents included HIV-positive and HIV-negative individuals at sexually transmitted disease clinics, college(More)
SETTING Tuberculosis Research Centre, Chennai, India. OBJECTIVE To evaluate a two-reagent cold staining method for detection of acid-fast bacilli in sputum smears. SPUTUM SAMPLES: Two hundred and forty-four samples from pulmonary tuberculosis patients attending Tuberculosis Research Centre were used. METHODS AND DESIGN Two smears were prepared from each(More)
A total of 114 strains of Mycobacterium tuberculosis isolated from sputum samples of 114 patients of pulmonary tuberculosis in south India, were coded and tested for their in vitro susceptibility to tuberactinomycin (Tum) incorporated in Lowenstein-Jensen (LJ) medium. Of these strains, 95 (83.3%) and 15 (13.2%) were susceptible to Tum at 25 and 50 mg/l(More)
Evaluation of newer methods and optimization of existing methods for the susceptibility testing of second-line drugs, especially ethionamide, are essential when treatment of multidrug-resistant tuberculosis (MDR-TB) is warranted. The ideal method must clearly demarcate sensitive from resistant strains. Hence, optimization of the conventional minimum(More)
SETTING Microscopy centres in Tiruvallur District, Tamil Nadu, India, implementing DOTS. OBJECTIVE To know whether washing new glass slides in dichromate solution is essential for effective sputum acid-fast bacilli microscopy. METHODS Two direct smears were prepared from each of 1750 sputum samples. One was made on dichromate solution-cleaned new glass(More)
BACKGROUND Microscopists opine that acid-alcohol decolourized slides may enhance acid-fast bacilli (AFB) smear positivity, and published documents on equivalence of acid and acid-alcohol in ZN staining method are not easily accessible. SETTING National Institute for Research in Tuberculosis, Chennai, India. OBJECTIVE To document the equivalence of 25%(More)
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