Fathia Khemiss

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OBJECTIVES Clopidogrel, a thienopyridine antiplatelet agent, is a poor aqueous soluble compound and a P-glycoprotein (P-gp) efflux pump substrate. These two factors are responsible for its incomplete intestinal absorption. In this study, we have attempted to enhance the absorption of clopidogrel by improving its solubility and by inhibiting intestinal P-gp(More)
Olea europaea L. is used in traditional medicine in the Mediterranean areas. Its natural products are used in the treatment of different disorders, like fighting fever and some infectious diseases such as malaria, the treatment of arrhythmia, and relief of intestinal spasms. The aim of the current study is to investigate the possible anti-inflammatory and(More)
PURPOSE Oral drug administration remains the most common and most convenient way used in clinical therapy. The availability of a simple, rapid, economic and reproducible in vitro method to assess the rate, extent and mechanism of intestinal drug absorption is a very helpful tool. The purpose of this study was to compare the performance of Sartorius SM 16750(More)
The everted gut sac technique has been used to investigate the effect of Vibrio vulnificus on water and electrolyte (Na(+), K(+), Cl(-), HCO(3)(-)) transport on the intestine of sea bream (Sparus aurata L.). Both the anterior and the posterior intestine were incubated in a medium containing 10(8) V. vulnificus cells ml(-1) at 25 degrees C for 2 h. The(More)
UNLABELLED Experimental osteoporosis was studied in mandible bone by means of ovariectomy and vitamin D insufficiency. METHODS 42 female Wistar rats were divided into the following four groups: (1) ovariectomized rats maintained in 12h day-night light conditions (ov-l), (2) ovariectomized rats maintained in 24h dark light conditions (ov-ob), (3)(More)
BACKGROUND Bisphosphonates are indicated for the treatment of osteoporosis. However, they could have an adverse effect on specific sites, such as the bisphosphonate-related osteonecrosis of the jaw. The aim of this study is to investigate the effect of etidronate on the resorption and apposition sides of the periodontium in ovariectomized rats. METHODS(More)
Grewia tenax roots, leaves, juice and fruit decoctions have been used in Africa and Southeast Asiatic countries for a variety of medical purposes. In this investigation, we report the effect of aqueous extract of Grewia tenax fruit (AEGTF) on the variation in vitro of iron absorption. The incubation of freshly prepared rat everted gut sac (EGS) in Ringer(More)
1. Total pancreatectomy in the goose, in addition to the effects previously described (fatal hypoglycaemia and impaired tolerance), increases markedly the plasma amino-acid level. This increase corresponds to a significant rise in individually tested plasma amino-acids. In addition, pancreatectomy suppresses the hyperglycaemia which normally follows(More)
In the goose, alanine and arginine, intravenously or orally administered, act in the same way on pancreatic hormones; they both stimulate insulin and glucagon secretions. Conversely, whereas alanine treatment has no effect on plasma gut GLI, oral arginine stimulates gut GLI secretion. Since stimulation of gut GLI secretion does not occur with i.v. arginine,(More)
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