Fatheya M. Metwally

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Invasion and metastasis of solid tumors require proteolytic enzymes for degradation of the basal membrane and extracellular matrix. Currently, there are no reliable methodologies to predict the risk for metastatic disease. In this context, our aim has been focused on the development of a noninvasive score based on tumor-associated trypsin inhibitor (TATI)(More)
Tumor metastasis involves the dissemination of malignant cells into the basement membrane, and the vascular system contributes to the circulating pool of these markers. In this context, our aim has been focused on the development of a non-invasive score based on degradation of the backbone of glycosaminoglycans of the extracellular matrix; namely hyaluronic(More)
Tumor growth can cause antioxidant disturbances in certain tissues of the tumor host. So, we examined the antioxidant system as a possible mechanism through which Neem leaves preparation (NLP) exerts its oncostatic potential. Female Swiss Albino mice were inoculated intramuscularly in the right thigh with Ehrlich ascites carcinoma (EAC) cells. NLP (500(More)
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