Fatemeh Hadaeghi

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Bipolar disorder is characterized by repeated erratic episodes of mania and depression, which can be understood as pathological complex system behavior involving cognitive, affective and psychomotor disturbance. In order to illuminate dynamical aspects of the longitudinal course of the illness, we propose here a novel complex model based on the notion of(More)
The brain presents a large number of spatially connected and interacting neu-rons and synapses that form many positive and negative feedback circuits. These complex networks in interaction with the environment have been experimentally demonstrated to produce temporally chaotic behavior which may be detected in recordings from individual nerve cells or(More)
Multiple Sclerosis (MS) is a devastating autoimmune disease which deteriorates the connections in central nervous system (CNS) through the attacks to oligodendrocytes. Studying its origin and progression, in addition to clinical developments such as MRI brain images, cerebrospinal fluid (CSF) variation and quantitative measures of disability (EDSS), which(More)
IMPORTANCE In the absence of a comprehensive neural model to explain the underlying mechanisms of disturbed circadian function in bipolar disorder, mathematical modeling is a helpful tool. Here, circadian activity as a response to exogenous daily cycles is proposed to be the product of interactions between neuronal networks in cortical (cognitive(More)
Cardiac muscle is a syncytial tissue of electrically coupled cells in which excitation of one cardiomyocyte spreads to all car-diomyocytes. Mechanisms of cell coupling in myocardial tissue can be categorized in two main groups: mechanisms that connect the intracellular parts of myocytes together (i.e., gap junctions), and mechanisms that act through changes(More)
What is the mathematical description of the treated mood pattern in bipolar disorder? In their innovative article, Daugherty et al. (2009) have modeled the mood swings of a patient with bipolar disorder as a Liénard oscillator with autonomous forcing. They proposed that emotional state of untreated and treated bipolar type-II patient could be mathematically(More)
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