Farzaneh Ganji

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Under congenital thyroid hypofunction, the oro-facial large and small calcitonin gene-related peptide (CGRP) immunoreactive motoneurons were classified into strong, moderate, weak and negative intensity in offspring weaned rats. While 50% of neurons in the trigeminal motor nucleus (Mo5) were of the large type, this value dropped to 30% in hypothyroid pups.(More)
It has been known that an intact thyroid hormone is obligatory for the attainment of the normal masticatory function at the time of weaning. Following induced maternal thyroid hypo-function, the development of masseter motoneurons was determined at postnatal days 1, 7, 15 and 23 (weaning time), using retrograde transport of horseradish peroxidase (HRP) in(More)
A novel injectable in situ gelling thermosensitive chitosan-block-poly(ethylene glycol) formulation was synthesized for drug delivery applications. Block copolymerization of monomethoxy–poly(ethylene gly-col) onto chitosan using potassium persulfate as an initiator was carried under a nitrogen atmosphere in aqueous solution. The effects of potassium(More)
Introduction The brain has a fully functional angiotensin system that mediates local generation of angiotensin II by the angiotensin-converting enzyme (Wright and Harding, 2010). The renin-angiotensin system (RAS) in the brain is well known to be involved in systemic blood pressure control (de Gasparo et al., 2000). Some recent reports have shown that this(More)
Oxidative stress is a major pathogenic mechanism of lead neurotoxicity. The antioxidant ascorbic acid protects hippocampal pyramidal neurons against cell death during congenital lead exposure; however, critical functions like synaptic transmission, integration, and plasticity depend on preservation of dendritic and somal morphology. This study was designed(More)
Introduction: Appropriate thyroid hormone (TH) levels are essential during the critical period of brain
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