Learn More
In situ gelling systems are very attractive for pharmaceutical applications due to their biodegradability and simple manufacturing processes. The synthesis and characterization of thermosensitive poly(d,l-lactic-co-glycolic acid) (PLGA)–polyethylene glycol (PEG)–PLGA triblock copolymers as in situ gelling matrices were investigated in this study as a drug(More)
Intracranial pressure (ICP) is derived from cerebral blood pressure and cerebrospinal fluid (CSF) circulatory dynamics and can be affected in the course of many diseases. Computer analysis of the ICP time pattern plays a crucial role in the diagnosis and treatment of those diseases. This study proposes the application of Linninger et al.'s [IEEE Trans.(More)
Recently, great attention has been paid to in situ gel-forming chitosan/glycerol-phosphate (chitosan/Gp) solution due to their good biodegradability and thermosensitivity. This in situ gel-forming system is injectable fluid that can be introduced into the body in a minimally invasive manner prior to solidifying within the desired tissue. At the present(More)
A novel injectable in situ gelling thermosensitive chitosan-block-poly(ethylene glycol) formulation was synthesized for drug delivery applications. Block copolymerization of monomethoxy–poly(ethylene gly-col) onto chitosan using potassium persulfate as an initiator was carried under a nitrogen atmosphere in aqueous solution. The effects of potassium(More)
  • 1