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In mesial temporal lobe (MTL) epilepsy, which typically involves the hippocampus (HPC), epileptiform events are enhanced during slow wave sleep (SWS). It remains unclear how and why the electroencephalographic (EEG) states that constitute SWS might predispose the HPC to this type of pathological activity. Recently our laboratory has described a novel state(More)
Non-REM (slow-wave) sleep has been shown to facilitate temporal lobe epileptiform events, whereas REM sleep seems more restrictive. This state-dependent modulation may be the result of the enhancement of excitatory synaptic transmission and/or the degree of network synchronization expressed within the hippocampus of the temporal lobe. The slow oscillation(More)
33 Non-REM (slow-wave) sleep has been shown to facilitate temporal lobe epileptiform 34 events, whereas REM sleep appears more restrictive. This state-dependent modulation 35 may be the result of the enhancement of excitatory synaptic transmission and/or the 36 degree of network synchronization expressed within the hippocampus of the temporal 37 lobe. The(More)
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