Farhan F Malik

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Mice exposed to high concentrations of ethanol vapour (25-38 mg/l of inhaled air) for 24 h develop leucopenia, neutropenia, lymphopenia, monocytopenia and thrombocytopenia but not anaemia or macrocytosis. Their bone marrows usually give normal deoxyuridine-suppressed values and contain normal numbers of granulocyte-macrophage progenitor cells and slightly(More)
The effects of culturing four human cell lines--Raji, MOLT-4, WI-L2, and K562--in the presence of 10-360 microM acetaldehyde for 3-18 days have been investigated. Concentrations of 45-360 microM caused a prolongation of the cell doubling time, and those of 90-360 microM caused an increase in the modal cell volume and in the protein content per cell. The(More)
Atopic, obese asthmatics exhibit airway obstruction with variable degrees of eosinophilic airway inflammation. We previously reported that mice obese as a result of a genetic deficiency in either leptin (ob/ob mice) or the long isoform of the leptin receptor (db/db mice) exhibit enhanced airway obstruction in the presence of decreased numbers of(More)
Acute exposure to ozone (O3), an air pollutant, causes pulmonary inflammation, airway epithelial desquamation, and airway hyperresponsiveness (AHR). Pro-inflammatory cytokines-including IL-6 and ligands of chemokine (C-X-C motif) receptor 2 [keratinocyte chemoattractant (KC) and macrophage inflammatory protein (MIP)-2], TNF receptor 1 and 2 (TNF), and type(More)
The surgical correction of congenital cardiac lesions that are complicated by intercurrent respiratory syncytial virus (RSV) pneumonitis has traditionally been deferred for at least 6 to 8 weeks. The presumption is that using cardiopulmonary bypass will increase the risk of postoperative pulmonary complications. We present an infant who developed acute(More)
Paul H. Dahm, Jeremy B. Richards, Harry Karmouty-Quintana, Kevin R. Cromar, Sanjiv Sur, Roger E. Price, Farhan Malik, Chantal Y. Spencer, Ramon X. Barreno, Syed S. Hashmi, Michael R. Blackburn, Ikram U. Haque, and Richard A. Johnston Division of Critical Care Medicine, Department of Pediatrics, The University of Texas Medical School at Houston, Houston,(More)
Expression of plasminogen activator inhibitor (PAI)-1, the major physiological inhibitor of fibrinolysis, is increased in the lung following inhalation of ozone (O3), a gaseous air pollutant. PAI-1 regulates expression of interleukin (IL)-6, keratinocyte chemoattractant (KC), and macrophage inflammatory protein (MIP)-2, which are cytokines that promote lung(More)
Inbred strain 2 and random-bred guinea pigs injected oxazolone in incomplete or complete Freund's adjuvant showed contact reactions within an hour after topical application when tested 3 weeks post-sensititization. The application when tested 3 weeks post-sensitization. The time for appearance of skin reactions at 5 days post-sensitization was 8 to 24 hr,(More)
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