Fansuo Zeng

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  • F Zeng, J Wess
  • 2000
The five muscarinic acetylcholine receptors (M(1)-M(5)) are prototypical members of the superfamily of G-protein-coupled receptors (GPCRs). During the past decade, this laboratory has used different members of this receptor subfamily as model systems to study the molecular mechanisms involved in GPCR function. This article reviews recent investigations(More)
The N termini of two G protein alpha subunits, alphaq and alpha11, differ from those of other alpha subunits in that they display a unique, highly conserved six-amino acid extension (MTLESI(M)). We recently showed that an alphaq deletion mutant lacking these six amino acids (in contrast to wild type alphaq) was able to couple to several different Gs- and(More)
Most G protein-coupled receptors contain a conserved pair of extracellular cysteine residues that are predicted to form a disulfide bond linking the first and second extracellular loops. Previous studies have shown that this disulfide bond may be critical for ligand binding, receptor activation, and/or proper receptor folding. However, the potential(More)
Evidence supporting nitric oxide (NO) as a mediator of plant biochemistry continues to grow, but its functions at the molecular level remains poorly understood and, in some cases, controversial. To study the role of NO at the transcriptional level in Betula platyphylla cells, we conducted a genome-scale transcriptome analysis of these cells. The(More)
In this study, we investigated the physiological and gene expression responses of Fraxinus interspecific hybrids seedlings to short-term artificially-applied drought stress. Experiment results showed that there were differences in physiological and gene expression responses between hybrids and their parents. Hybrid D110 kept higher levels of photosynthetic(More)
The structural basis underlying the G protein coupling selectivity of different muscarinic receptor subtypes was analyzed by using a combined molecular genetic/biochemical approach. These studies led to the identification of key residues on the receptors as well as the associated G proteins that are critically involved in determining proper receptor/G(More)
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