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Cofilin 1-Mediated Biphasic F-Actin Dynamics of Neuronal Cells Affect Herpes Simplex Virus 1 Infection and Replication
TLDR
The biphasic F-actin dynamics in HSV-1 neuronal infection is demonstrated for the first time and the association of F-Actin with the changes in the expression and activity of cofilin 1 is confirmed to provide insight into the mechanism by which HSV -1 productively infects neuronal cells and causes pathogenesis.
Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding Yeast
TLDR
It is shown here that the Wee1 ortholog Swe1 does indeed inhibit M-CDK activity and chromosome segregation in response to genotoxic insults and that Swe1 dispensability in budding yeast is the result of a redundant control of M- CDK activity by the checkpoint kinase Rad53.
Polyhydroxy steroids and saponins from China Sea starfish Asterina pectinifera and their biological activities.
A new polyhydroxy sterol ester, (25S)-5alpha-cholestane-3beta,6alpha,7alpha,8,15alpha,16beta-hexahydroxyl-26-O-14'Z-eicosenoate (1), together with seven known steroid derivatives (2-8), were isolated
Microarray Analysis of the Chelerythrine-Induced Transcriptome of Mycobacterium tuberculosis
TLDR
To reveal the possible mechanism of action of chelerythrine against Mycobacteriumtuberculosis, commercial oligonucleotide microarrays were used to analyze the genome-wide transcriptional changes triggered by treatment with subinhibitory concentrations of cheerythrine and produced the first insights into the response of M. tuberculosis to a chelersythrine challenge.
Bioactive dammarane-type saponins from Operculina turpethum.
TLDR
Four new dammarane-type saponins, operculinosides A-D (1-4), were isolated from the aerial parts of Operculina turpethum and showed significant protective activities against d-galactosamine-induced toxicity in L-02 human hepatic cells.
A restriction-free method for gene reconstitution using two single-primer PCRs in parallel to generate compatible cohesive ends
TLDR
The method provides an alternative cloning method capable of inserting any DNA fragment of up to at least 20 kb into a plasmid, with high efficiency, and is suitable for high-throughput cloning and structural genomics.
In vitro synergistic activity between 8-methoxypsoralen and ethambutol, isoniazid, and rifampin when used in combination against Mycobacterium tuberculosis
TLDR
It is shown that 8-MOP has antimycobacterial activity against two drug-sensitive and six drug-resistant clinical isolates of M. tuberculosis, and it is first report that 7-Mop has synergistic activity with first-line antimyCobacterial agents.
In vitro synergistic interactions of oleanolic acid in combination with isoniazid, rifampicin or ethambutol against Mycobacterium tuberculosis.
TLDR
It is found that oleanolic acid had antimycobacterial properties against eight clinical isolates of M. tuberculosis and exhibited a relatively low cytotoxicity in Vero cells, indicating that OA may serve as a promising lead compound for future antimyCobacterial drug development.
AFEAP cloning: a precise and efficient method for large DNA sequence assembly
TLDR
AFEAP cloning provides a powerful, efficient, seamless, and sequence-independent DNA assembly tool for multiple fragments up to 13 and large DNA up to 200 kb that expands synthetic biologist’s toolbox.
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