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China has about one-fifth of the world’s population, and this is a large number. To determine this large population number is important not only for policy-making and economic aspects but it is also very important for the purpose of osteoporosis prevention and treatment. According to the recommendations of the United Nations, many countries in the world(More)
Long noncoding RNAs (lncRNA) are emerging as key molecules in human cancer. Prostate cancer-associated ncRNA transcripts 1 (PCAT-1), a lncRNA, has been recently revealed involving in human prostate cancer progression. However, whether PCAT-1 could serve as novel biomarker to predict prognosis in colorectal cancer (CRC) or not is unknown. We therefore(More)
Speech productions of 40 English- and 40 Japanese-speaking children (aged 2-5) were examined and compared with the speech produced by 20 adult speakers (10 speakers per language). Participants were recorded while repeating words that began with "s" and "sh" sounds. Clear language-specific patterns in adults' speech were found, with English speakers(More)
Many of the important changes in evolution are regulatory in nature. Sequenced bacterial genomes point to flexibility in regulatory circuits but we do not know how regulation is remodeled in evolving bacteria. Here, we study the regulatory changes that emerge in populations evolving under controlled conditions during experimental evolution of Escherichia(More)
This paper examines the acoustic characteristics of voiceless sibilant fricatives in English-and Japanese-speaking adults and the acquisition of contrasts involving these sounds in 2- and 3-year-old children. Both English and Japanese have a two-way contrast between an alveolar fricative (/s/), and a postalveolar fricative (/∫/ in English and /ɕ/ in(More)
Most acoustic studies of sibilant fricatives focus on languages that have a place distinction like the English distinction between coronal alveolar /s/ and coronal post-alveolar / /. Much less attention has been paid to languages such as Japanese, where the contrast involves tongue posture as much as position. That is, the Japanese sibilant that contrasts(More)
l-Serine is a nonessential amino acid, but plays a crucial role as a building block for cell growth. Currently, l-serine production is mainly dependent on enzymatic or cellular conversion. In this study, we constructed a recombinant Escherichia coli that can fermentatively produce l-serine from glucose. To accumulate l-serine, sdaA encoding the l-serine(More)
In the current study, the small RNA ryhB, which regulates the metabolism of iron in Escherichia coli, was constitutively expressed in engineered E. coli DALA. The resulting strain E. coli DALRA produced 16% more 5-aminolevulinic acid (ALA) than the parent strain E. coli DALA in batch fermentation. Meanwhile, we found that addition of iron in the medium(More)
Many microorganisms, growing on aging flue-cured tobacco leaves, play a part in its fermentation process. These microflora were identified and described by culture-dependent methods earlier. In this study we report the identity of the microflora growing on the tobacco leaf surface by employing culture-independent methods. We have amplified microbial 16S(More)
Three permeases, Mtr, TnaB, and AroP, are involved in the uptake of L-tryptophan in Escherichia coli. These permeases possess individual function for cell transportation and metabolism, and affect extracellular L-tryptophan accumulation. In this study, by knocking out three tryptophan permeases separately and simultaneously in L-tryptophan-producing strain(More)