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Current Web search engines are built to serve all users, independent of the special needs of any individual user. Personalization of Web search is to carry out retrieval for each user incorporating his/her interests. We propose a novel technique to learn user profiles from users' search histories. The user profiles are then used to improve retrieval(More)
(NIST) promotes the U.S. economy and public welfare by providing technical leadership for the nation " s measurement and standards infrastructure. ITL develops tests, test methods, reference data, proof of concept implementations, and technical analysis to advance the development and productive use of information technology. ITL " s responsibilities include(More)
Akt (also known as PKB), a serine/threonine kinase involved in diverse signal-transduction pathways, is highly expressed in the brain. Akt is known to have a strong antiapoptotic action and thereby to be critically involved in neuronal survival, but its potential role in the dynamic modulation of synaptic transmission is unknown. Here we report that Akt(More)
Dopamine D1-like receptors, composed of D1 and D5 receptors, have been documented to modulate glutamate-mediated fast excitatory synaptic neurotransmission. Here, we report that dopamine D1 receptors modulate NMDA glutamate receptor-mediated functions through direct protein-protein interactions. Two regions in the D1 receptor carboxyl tail can directly and(More)
Hippocampal CA1 homosynaptic long-term potentiation (LTP) is expressed specifically at activated synapses. Increased insertion of postsynaptic alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptors (AMPARs) appears to be crucial for CA1 LTP. However, the mechanism underlying AMPAR insertion during LTP remains largely unknown. We now report that(More)
With the amount of available text data in relational databases growing rapidly, the need for ordinary users to search such information is dramatically increasing. Even though the major RDBMSs have provided full-text search capabilities, they still require users to have knowledge of the database schemas and use a structured query language to search(More)
This study investigated whether congenital amusia, a neuro-developmental disorder of musical perception, also has implications for speech intonation processing. In total, 16 British amusics and 16 matched controls completed five intonation perception tasks and two pitch threshold tasks. Compared with controls, amusics showed impaired performance on(More)
Dopamine-glutamate interactions in the neostriatum determine psychostimulant action, but the underlying molecular mechanisms remain elusive. Here we found that dopamine stimulation by cocaine enhances a heteroreceptor complex formation between dopamine D2 receptors (D2R) and NMDA receptor NR2B subunits in the neostriatum in vivo. The D2R-NR2B interaction is(More)
Current web search engines are built to serve all users, independent of the needs of any individual user. Personalization of web search is to carry out retrieval for each user incorporating his/her interests. We propose a novel technique to map a user query to a set of categories, which represent the user's search intention. This set of categories can serve(More)