Learn More
Transcription factors (TFs) and their specific interactions with targets are crucial for specifying gene-expression programs. To gain insights into the transcriptional regulatory networks in embryonic stem (ES) cells, we use chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing (ChIP-seq) to map the locations of 13(More)
The primate visual system is believed to comprise two main pathways: a ventral pathway for conscious perception and a dorsal pathway that can process visual information and guide action without accompanying conscious knowledge. Evidence for this theory has come primarily from studies of neurological patients and animals. Using fMRI, we show here that even(More)
Here we develop an option pricing method for European options based on the Fourier-cosine series, and call it the COS method. The key insight is in the close relation of the characteristic function with the series coefficients of the Fourier-cosine expansion of the density function. In most cases, the convergence rate of the COS method is exponential and(More)
Are there neurons representing specific views of objects in the human visual system? A visual selective adaptation method was used to address this question. After visual adaptation to an object viewed either 15 or 30 degrees from one side, when the same object was subsequently presented near the frontal view, the perceived viewing directions were biased in(More)
We present a pricing method based on Fourier-cosine expansions for early-exercise and discretely-monitored barrier options. The method works well for exponential Lévy asset price models. The error convergence is exponential for processes characterized by very smooth (C ∞ [a, b] ∈ R) transitional probability density functions. The computational complexity is(More)
Two functional magnetic resonance imaging (fMRI) face viewpoint adaptation experiments were conducted to investigate whether fMRI adaptation in high-level visual cortex depends on the duration of adaptation and how different views of a face are represented in the human visual system. We found adaptation effects in multiple face-selective areas, which(More)
Adaptation is a general property of almost all neural systems and has been a longstanding tool of psychophysics because of its power to isolate and temporarily reduce the contribution of specific neural populations. Recently, adaptation designs have been extensively applied in functional MRI (fMRI) studies to infer neural selectivity in specific cortical(More)
Adaptation to a visual pattern can alter the sensitivities of neuronal populations encoding the pattern, which usually results in a visual aftereffect. However, the functional role of visual adaptation is still equivocal and its relation to visual aftereffect is largely unknown, especially for high-level visual adaptation. In this study, we took advantage(More)
We used functional magnetic resonance imaging (fMRI) to measure activity in human visual cortex, including a higher object processing area, the lateral occipital complex (LOC), and primary visual cortex (V1), in response to a perceptually bistable stimulus whose elements were perceived as either grouped into a shape or randomly arranged. We found activity(More)
MOTIVATION We introduce a dual multiple change-point (MCP) model for recombination detection among aligned nucleotide sequences. The dual MCP model is an extension of the model introduced previously by Suchard and co-workers. In the original single MCP model, one change-point process is used to model spatial phylogenetic variation. Here, we show that using(More)