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Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats
BackgroundThe body is unable to repair and regenerate large area bone defects. Moreover, the repair capacity of articular cartilage is very limited. There has long been a lack of effective treatmentsExpand
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Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability
Steroid-associated osteonecrosis of the femoral head remains a challenging problem in orthopedics worldwide. One pathomechanism is ischemia of the femoral head, as a result of thrombus formation andExpand
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Pulmonary radiological change of COVID-19 patients with 99mTc-MDP treatment
Background: As increasing cases of COVID-19 around world, urgent need for effective COVID-19-specific therapeutic drugs is necessary; therefore, we conducted a pilot randomized-controlled study toExpand
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TGF-β1 promotes the osteoinduction of human osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway
Transforming growth factor β1 (TGF-β1) has been suggested to be a candidate cytokine in the field of bone tissue engineering. Cytokines serve important roles in tissue engineering, particularly inExpand
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Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali–Acid-Heat and Hydrothermal Treatments
Porous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect repairs. However, insufficient osteointegration and osteoinduction still remain to open as oneExpand
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High-purity weight-bearing magnesium screw: Translational application in the healing of femoral neck fracture.
Magnesium (Mg)-based metals can be used as next-generation fracture internal fixation devices due to their specific properties. We used vascularized bone grafting fixed by degradable pure Mg screwsExpand
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Bone marrow mesenchymal stem cell-derived exosomes promote plasminogen activator inhibitor 1 expression in vascular cells in the local microenvironment during rabbit osteonecrosis of the femoral head
  • L. Li, Yikai Wang, +12 authors D. Zhao
  • Medicine
  • Stem cell research & therapy
  • 11 November 2020
Background Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to beExpand
Porous silicon carbide coated with tantalum as potential material for bone implants
Abstract Porous silicon carbide (SiC) has a specific biomorphous microstructure similar to the trabecular microstructure of human bone. Compared with that of bioactive ceramics, such as calciumExpand
A Ca-deficientca-deficient hydroxyapatite (CDHA)/MgF2 bi-layer coating with unique nano-scale topography on biodegradable high-purity Mg.
  • Junlei Li, Wenwu Xu, +7 authors K. Yang
  • Materials Science, Medicine
  • Colloids and surfaces. B, Biointerfaces
  • 27 February 2020
Enhanced corrosion resistance and accelerated new bone formation are desired to make Mg and its alloys to be ideal candidate for bone biomaterial. For this purpose, a CDHA/MgF2 bi-layer coating wasExpand