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  • Salvatore Cisternino, Claire Mercier, Fanchon Bourasset, Françoise Roux, Jean‐Michel Scherrmann
  • Medicine, Biology
  • Cancer research
  • 2004 (First Publication: 1 May 2004)
  • The breast cancer resistance protein (BCRP/ABCG2) is, like P-glycoprotein (P-gp), a member of the ABC family of drug transporters. These proteins actively transport various anticancer drugs fromContinue Reading
  • Tuan Minh Do, Marie-Sophie Noel-Hudson, +10 authors Fanchon Bourasset
  • Biology, Medicine
  • Journal of Alzheimer's disease : JAD
  • 2012 (First Publication: 4 May 2012)
  • The accumulation of amyloid-β peptide (Aβ) in the brain is a critical hallmark of Alzheimer's disease. This high cerebral Aβ concentration may be partly caused by impaired clearance of Aβ across theContinue Reading
  • Fanchon Bourasset, Salvatore Cisternino, Jamal Temsamani, Jean‐Michel Scherrmann
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 2003 (First Publication: 29 August 2003)
  • Morphine-6-beta-d-glucuronide (M6G) is an active metabolite of morphine with high analgesic potency despite a low blood-brain barrier (BBB) permeability. The aim of the study was to elucidate itsContinue Reading
  • Salvatore Cisternino, Fanchon Bourasset, Yves Archimbaud, Dorothée Sémiond, Gérard Sanderink, Jean‐Michel Scherrmann
  • Chemistry, Medicine
  • British journal of pharmacology
  • 2003 (First Publication: 1 April 2003)
  • 1. TXD258, a new taxoid antitumor agent, is a poor substrate for the P-glycoprotein (P-gp) in Caco-2 cells. In this study, we investigated the amount of drug accumulating in the brains of rats andContinue Reading
  • Hélène Chapy, Bruno Saubaméa, +5 authors Salvatore Cisternino
  • Chemistry, Medicine
  • British journal of pharmacology
  • 2016 (First Publication: 1 February 2016)
  • BACKGROUND AND PURPOSE The respective impact and interplay between ABC (P-glycoprotein/P-gp/Abcb1a, BCRP/ABCG2, MRP/ABCC) and SLC transporter functions at the blood-brain barrier (BBB) andContinue Reading
  • Tuan Minh Do, Agnès Dodacki, +5 authors Fanchon Bourasset
  • Biology, Medicine
  • Journal of Alzheimer's disease : JAD
  • 2016 (First Publication: 9 October 2015)
  • The involvement of transporters located at the blood-brain barrier (BBB) has been suggested in the control of cerebral Aβ levels, and thereby in Alzheimer's disease (AD). However, little is knownContinue Reading
  • Patrick Hindlet, André Bado, +5 authors Marion Buyse
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2009 (First Publication: 13 March 2009)
  • Leptin is a major determinant of energy homeostasis, acting both centrally and in the gastrointestinal tract. We previously reported that acute leptin treatment enhances the absorption of di- andContinue Reading
  • Agnès Dodacki, Matthew D. Wortman, +9 authors Fanchon Bourasset
  • Medicine, Chemistry
  • Scientific Reports
  • 2017 (First Publication: 17 October 2017)
  • ABCG4 is an ATP-binding cassette transmembrane protein which has been shown, in vitro, to participate in the cellular efflux of desmosterol and amyloid-β peptide (Aβ). ABCG4 is highly expressed inContinue Reading
  • Tuan Minh Do, Beatrice Bedussi, +6 authors Fanchon Bourasset
  • Psychology, Medicine
  • Journal of Alzheimer's disease : JAD
  • 2013 (First Publication: 9 July 2013)
  • The influx of amyloid-β peptide (Aβ) across the blood-brain barrier is partly mediated by the receptor for advanced glycation end products (RAGE). But other transporters, like Oatp (organic anionContinue Reading