Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.
- Fan Yang, M. Hamann, Hou‐Wen Lin
- ChemistryJournal of Natural Products
- 23 February 2012
Four new alkaloids isolated from the marine sponge Agelas mauritiana showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro and exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aUREus in vitro.
New butenolide derivatives from the marine sponge-derived fungus Aspergillus terreus.
- Yating Sun, Jingtang Liu, Hou‐Wen Lin
- ChemistryBioorganic & Medicinal Chemistry Letters
- 1 December 2017
New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1
- Min-Jia Cao, Tao Zhu, Jingtang Liu, L. Ouyang, Fan Yang, Hou‐Wen Lin
- Medicine, ChemistryNatural Product Research
- 16 April 2019
Two new sorbicillinoids were isolated from the sponge-derived fungus Penicillium chrysogenum 581F1 and displayed high affinities to target proteins GLP-1R (diabetes) and eEF2K (cancer) with Kd values of 0.0285 μM, 0.0162‷μM and 0.0746M, respectively.
Reniochalistatins A-E, cyclic peptides from the marine sponge Reniochalina stalagmitis.
- Kai-xuan Zhan, Wei-Hua Jiao, Hou‐Wen Lin
- Chemistry, BiologyJournal of Natural Products
- 9 December 2014
The cyclic octapeptide reniochalistatin E showed biological activity in various cytotoxicity assays employing different tumor cell lines (RPMI-8226, MGC-803, HL-60, HepG2, and HeLa).
Hippolachnin A, a new antifungal polyketide from the South China Sea sponge Hippospongia lachne.
- Shu-juan Piao, Yun-long Song, Hou‐Wen Lin
- BiologyOrganic Letters
- 5 July 2013
Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, Cryptococcus neoformans, Trichophyton rubrum, and Microsporum gypseum, with a MIC value of 0.41 μM for each fungus.
Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne.
- Shu-juan Piao, Hong-jun Zhang, Hou‐Wen Lin
- Chemistry, BiologyJournal of Natural Products
- 6 May 2011
Eight new acyclic manoalide-related sesterterpenes, hippolides A-H (1-8), together with two known manoalide derivatives, (6E)-neomanoalide (9) and (6Z)-neomanoalide (10), were isolated from the South…
Proline-containing cyclopeptides from the marine sponge Phakellia fusca.
- Hong-jun Zhang, Y. Yi, Hou‐Wen Lin
- Chemistry, BiologyJournal of Natural Products
- 26 March 2010
Four new cyclopeptides, phakellistatins 15-18 (2-5), together with five known cyclopeptides, phakellistatin 13 (1), hymenistatin 1, and hymenamides G, H, and J, were isolated from the South China Sea…
Dysideanones A-C, unusual sesquiterpene quinones from the South China Sea sponge Dysidea avara.
- Wei-Hua Jiao, Ting-ting Xu, Hou‐Wen Lin
- ChemistryJournal of Natural Products
- 18 February 2014
Dysideanones A-C (1-3), three unusual sesquiterpene quinones with unprecedented carbon skeletons, were isolated from the South China Sea sponge Dysidea avara and showed cytotoxicity against two human cancer cell lines.
Sesterterpenes and a New Sterol from the Marine Sponge Phyllospongia foliascens
- Hong-jun Zhang, Y. Yi, Fan Yang, Wan-sheng Chen, Hou‐Wen Lin
- ChemistryMolecules
- 1 February 2010
A new scalarane sesterterpene, phyllofolactone M (1), and a new sterol, (24E)-5α,6α-epoxystigmasta-7,24(28)-dien-3β-ol (3), together with a known sesterterpene, phyllofolactone B (2), were isolated…
New diterpene alkaloids from the marine sponge Agelas mauritiana
- Li-Li Hong, Jia-Bao Sun, Hou‐Wen Lin
- Chemistry
- 3 May 2017
Chemical investigation of an ethanol extract of the sponge Agelas mauritiana led to the isolation and characterization of five new diterpene alkaloids, namely, (−)-8′-oxo-agelasine B (1),…
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