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While numerous algorithms have been proposed for object tracking with demonstrated success, it remains a challenging problem for a tracker to handle large change in scale, motion, shape deformation with occlusion. One of the main reasons is the lack of effective image representation to account for appearance variation. Most trackers use high-level(More)
X inactivation equalizes the dosage of gene expression between the sexes, but some genes escape silencing and are thus expressed from both alleles in females. To survey X inactivation and escape in mouse, we performed RNA sequencing in Mus musculus x Mus spretus cells with complete skewing of X inactivation, relying on expression of single nucleotide(More)
Kineograph is a distributed system that takes a stream of incoming data to construct a continuously changing graph, which captures the relationships that exist in the data feed. As a computing platform, Kineograph further supports graph-mining algorithms to extract timely insights from the fast-changing graph structure. To accommodate graph-mining(More)
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an(More)
Deep convolutional neural networks have been successfully applied to image classification tasks. When these same networks have been applied to image retrieval, the assumption has been made that the last layers would give the best performance, as they do in classification. We show that for instance-level image retrieval, lower layers often perform better(More)
TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term 'equivalog' to describe members of a set of homologous proteins that are conserved with respect to(More)
FOXO1A and FOXO3A are two members of the FoxO family. FOXO3A has recently been linked to human longevity in Japanese, German and Italian populations. Here we tested the genetic contribution of FOXO1A and FOXO3A to the longevity phenotype in Han Chinese population. Six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and(More)
Temporal graphs capture changes in graphs over time and are becoming a subject that attracts increasing interest from the research communities, for example, to understand temporal characteristics of social interactions on a time-evolving social graph. Chronos is a storage and execution engine designed and optimized specifically for running in-memory(More)
To achieve a balanced gene expression dosage between males (XY) and females (XX), mammals have evolved a compensatory mechanism to randomly inactivate one of the female X chromosomes. Despite this chromosome-wide silencing, a number of genes escape X inactivation: in women about 15% of X-linked genes are bi-allelically expressed and in mice, about 3%.(More)
In this paper, we investigate two new strategies to detect objects accurately and efficiently using deep convolutional neural network: 1) scale-dependent pooling and 2) layerwise cascaded rejection classifiers. The scale-dependent pooling (SDP) improves detection accuracy by exploiting appropriate convolutional features depending on the scale of candidate(More)