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The bioactive lipid mediator platelet activating factor (PAF) is recognized as a key effecter of neuronal apoptosis, yet it is not clear whether its G-protein coupled receptor (PAFR) initiates or prevents PAF neurotoxicity. Using PAFR-/- and congenic wild-type mice, we show that PAF triggers caspase-3/7 activity and neuronal death in PAFR-/- but not PAFR+/+(More)
Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable patient-derived prostate cancer xenografts that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development. Xenografts preserved the(More)
A regular circuit structure called a River PLA and its re-configurable version, Glacier PLA, are presented. River PLAs provide greater regularity than circuits implemented with standard-cells. Conventional optimization stages such as technology mapping, placement and routing are eliminated. These two features make the River PLA a highly predictable(More)
RNA-seq is a powerful tool for comprehensive characterization of whole transcriptome at both gene and exon levels and with a unique ability of identifying novel splicing variants. To date, RNA-seq analysis of HBV-related hepatocellular carcinoma (HCC) has not been reported. In this study, we performed transcriptome analyses for 10 matched pairs of cancer(More)
A new routing algorithm is presented. It is based on a multiple star net model, force-directed placement and maze searching techniques. The algorithm inherits the power of maze routing in that it is able to route complex layouts with various obstructions. The large memory requirement of the conventional maze algorithm is alleviated through successive net(More)