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Sperm and eggs carry distinctive epigenetic modifications that are adjusted by reprogramming after fertilization. The paternal genome in a zygote undergoes active DNA demethylation before the first mitosis. The biological significance and mechanisms of this paternal epigenome remodelling have remained unclear. Here we report that, within mouse zygotes,(More)
Given a terabyte click log, can we build an efficient and effective click model? It is commonly believed that web search click logs are a gold mine for search business, because they reflect users' preference over web documents presented by the search engine. Click models provide a principled approach to inferring user-perceived relevance of web documents,(More)
In this paper, we propose an improved image dehazing algorithm using dark channel prior and Multi-Scale Retinex. Main improvement lies in automatic and fast acquisition of transmission map of the scene. We implement the Multi-scale Retinex algorithm on the luminance component in YCbCr space, obtain a pseudo transmission map whose function is similar to the(More)
A plausible representation of relational information among entities in dynamic systems such as a living cell or a social community is a stochastic network which is topologically rewiring and semantically evolving over time. While there is a rich literature on modeling static or temporally invariant networks, much less has been done toward modeling the(More)
Modern applications such as web knowledge base, network traffic monitoring and online social networks have made available an unprecedented amount of network data with rich types of interactions carrying multiple attributes, for instance, port number and time tick in the case of network traffic. The design of algorithms to leverage this structured(More)
Click models provide a principled way of understanding user interaction with web search results in a query session and a statistical tool for leveraging search engine click logs to analyze and improve user experience. An important component in all existing click models is the user behavior assumption -- how users scan, examine and click web documents listed(More)
DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic development. However, its dynamic patterns have not been analysed at the genome scale in human pre-implantation embryos due to technical difficulties and the scarcity of required materials. Here we systematically profile the methylome of human early embryos from the(More)
BACKGROUND Alzheimer's disease (AD) is a severe neurodegenerative disease for which there is currently no effective treatment. The purpose of this study was to investigate whether repeated electroacupuncture (EA) stimulation would improve cognitive function and the pathological features of AD in amyloid precursor protein (APP)/presenilin 1 (PS1) double(More)
We have previously shown that electroacupuncture (EA) pretreatment produces neuroprotective effects, which were mediated through an endocannabinoid signal transduction mechanism. Herein, we have studied the possible contribution of the phosphorylated form of glycogen synthase kinase-3β (GSK-3β) in EA pretreatment-induced neuroprotection via the cannabinoid(More)