Faming Zhang

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The NS5B RNA-dependent RNA polymerase encoded by hepatitis C virus (HCV) plays a key role in viral replication. Reported here is evidence that HCV NS5B polymerase acts as a functional oligomer. Oligomerization of HCV NS5B protein was demonstrated by gel filtration, chemical cross-linking, temperature sensitivity, and yeast cell two-hybrid analysis.(More)
Face recognition with single training sample has the problem that the sample is single and face pattern is changeable. The rate of traditional face recognition methods declines seriously in the case of single training sample. Thus, studying the face recognition method which is appropriate for single training sample is challenging in face recognition field.(More)
The NS5B RNA-dependent RNA polymerase encoded by the hepatitis C virus (HCV) is a key component of the viral replicase. Reported here is the three-dimensional structure of HCV NS5B polymerase, with the highlight on its C-terminal folding, determined by X-ray crystallography at 2.1-A resolution. Structural analysis revealed that a stretch of C-terminal(More)
Taxi trajectories reflect human mobility over a road network. Pickup and drop-off locations in different time periods represent origins and destinations of trips, respectively, demonstrating the spatiotemporal characteristics of human behavior. Each trip can be viewed as a displacement in the random walk model, and the distribution of extracted trips shows(More)
BACKGROUND Aggressive tumor cells can form perfusable networks that mimic normal vasculature and enhance tumor growth and metastasis. A number of molecular players have been implicated in such vasculogenic mimicry, among them the receptor tyrosine kinase EphA2, which is aberrantly expressed in aggressive tumors. Here we study the role and regulation of(More)
The prediction of travel times is challenging because of the sparseness of real-time traffic data and the intrinsic uncertainty of travel on congested urban road networks. We propose a new gradient–boosted regression tree method to accurately predict travel times. This model accounts for spatiotemporal correlations extracted from historical and real-time(More)
Although only 6% of the estimated 518 protein kinases [1] encoded in the human genome have had structures of their catalytic domains determined by X-ray crystallography, structure-based design techniques can significantly aid in the discovery of novel kinase inhibitors across this protein class. Conservation of the ATP binding site between known kinase(More)