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PURPOSE We determined the value of mandatory second opinion pathology review to interpret prostate needle biopsy before radical prostatectomy. MATERIALS AND METHODS In all cases referred to our institution for radical prostatectomy in 1 year we compared pathological parameters in original and reviewed pathology reports, including benign, atypical or(More)
Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinomas (RCC) are difficult to diagnose prospectively. We used immunohistochemistry (IHC) to identify fumarate hydratase (FH)-deficient tumors (defined as FH negative, 2-succinocysteine [2SC] positive) in cases diagnosed as "unclassified RCC, high grade or with papillary(More)
As epithelioid cellular morphology can be seen in clinically benign usual angiomyolipomas (AMLs), we divide epithelioid AMLs into those without and with atypia, the latter category associated in the literature with malignant potential. We herein report the histologic spectrum and biologic behavior of 40 consecutive cases of epithelioid AML with atypia and(More)
OBJECTIVES The goal of this study was to evaluate sensitivity and specificity of urine cytology during a contemporary period at our institution in comparison with historical analysis and other reported urinary biomarkers. MATERIALS AND METHODS Data from 1,114 consecutive patients corresponding to 3,251 specimens (2,979 cytologic and 272 histologic(More)
The "atypical urothelial cell" cytologic category is nonstandardized. We subclassify atypical cases to "atypical, favor a reactive process" or "atypical, unclear if reactive or neoplastic." We evaluated the predictive significance of atypical cases by looking at their histologic follow-up. Among the 1,114 patients and 3,261 specimens included, 282 specimens(More)
OBJECTIVES To assess whether reporting the grade of cancer at the site of positive margins in a radical prostatectomy (RP) specimen was independently prognostic of the outcome. METHODS We restricted our study to 108 patients with Gleason score (GS) 7, nonfocal extraprostatic extension (EPE) (Stage pT3a), and positive surgical margins. Patients with a(More)
Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV8)-associated large-cell non-Hodgkin lymphoma localized in body cavities and presenting as pleural, peritoneal, or pericardial lymphomatous effusions. It typically affects immunocompromised patients and usually involves only one body site. We describe herein a case of PEL affecting three body(More)
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare indolent subtype of renal cell carcinoma, which has variable magnetic resonance (MR) imaging features due to histomorphologic diversity. Diffusion-weighted MR imaging has shown its ability to differentiate benign and malignant renal neoplasms in some recent studies and can be a useful adjunct to(More)
CONTEXT Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary urothelial carcinoma (LG-UrCa) following implementation of the 2004 World Health Organization/International Society of Urological Pathology (WHO/ISUP) consensus classification. OBJECTIVE To evaluate our cohort of LG-UrCa cases classified according to(More)
OBJECTIVE The objective of our study was to determine whether there is a statistically significant correlation between metabolic activity of osseous and soft-tissue sarcomas as measured by the maximum standardized uptake value (SUV(max)) on (18)F-FDG PET/CT and histopathologic characteristics such as mitotic counts, the presence of necrosis, and the(More)