Fabrizio Michetti

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S100B is a calcium-binding protein concentrated in glial cells, although it has also been detected in definite extra-neural cell types. Its biological role is still debated. When secreted, S100B is believed to have paracrine/autocrine trophic effects at physiological concentrations, but toxic effects at higher concentrations. Elevated S100B levels in(More)
S-100 is a protein originally believed to be unique to the nervous system. We report here on the presence of S-100 in rat adipocytes, using immunohistochemical and immunochemical methods. We demonstrate that the protein in adipose tissue is present at a concentration comparable to that measured in the nervous tissue and is immunologically identical to brain(More)
S-100, a protein originally believed to be unique to the nervous system, has recently been found in extraneural presence of S-100 in the testis, namely in Leydig cells and in lymphatic endothelial cells, using immunohistochemical and immunochemical methods. We show that the protein in the testis is immunologically identical to brain S-100. The(More)
individuals 4, 5, and 6 were HbA/S heterozygotes and homozygous for non-E; individuals 7, 8, and 9 were homozygous for both HbS and non-E; and individuals 10, 11, and 12 were HbA homozygotes and non-E/HbE heterozygotes. These data also demonstrate an additional advantage of this multiplexed fluorescent bead arraybased approach. Because it is very rare for(More)
The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively involving the limbic system and especially marked in the hippocampus, makes it useful to obtain in vivo models of neurodegeneration associated with behavioural alterations, such as hyperactivity and aggression,(More)
Local gene transfer of the human Lim mineralization protein (LMP), a novel intracellular positive regulator of the osteoblast differentiation program, can induce efficient bone formation in rodents. To develop a clinically relevant gene therapy approach to facilitate bone healing, we have used primary dermal fibroblasts transduced ex vivo with Ad.LMP-3 and(More)
Recent evidence suggested that muscle degeneration might lead and/or contribute to neurodegeneration, thus it possibly play a key role in the etiopathogenesis and progression of amyotrophic lateral sclerosis (ALS). To test this hypothesis, this study attempted to categorize functionally relevant genes within the genome-wide expression profile of human ALS(More)
The presence of the nervous system-specific S-100 antigen has been tested by microcomplement fixation assay with a monospecific anti-S-100 antiserum in cerebrospinal fluid (CSF) of subjects suffering from psychiatric disorders or various neurological diseases. The antigen was detectable in the CSF of most of the patients with neurological diseases(More)