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SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.
Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved inExpand
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NK Cells Recognize and Kill Human Glioblastoma Cells with Stem Cell-Like Properties1
In this study, cancer cells were isolated from tumor specimens of nine glioblastoma patients. Glioblastoma cells, cultured under suitable culture conditions, displayed markers typical of neural stemExpand
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Comparative Analysis of DNA Repair in Stem and Nonstem Glioma Cell Cultures
It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. WeExpand
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Different Response of Human Glioma Tumor-initiating Cells to Epidermal Growth Factor Receptor Kinase Inhibitors*
Because a subpopulation of cancer stem cells (tumor-initiating cells, TICs) is believed to be responsible for the development, progression, and recurrence of many tumors, we evaluated the in vitroExpand
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Effects of Emx2 inactivation on the gene expression profile of neural precursors
Emx2 plays a crucial role in the development of the diencephalon and dorsal telencephalon. Thus, Emx2‐null mutants have abnormal cortical lamination and a reduction in size of the caudal and medialExpand
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Pituitary adenylate cyclase-activating polypeptide in the brain, spinal cord and sensory organs of the zebrafish, Danio rerio, during development.
The distribution of Pituitary adenylate cyclase-activating polypeptide (PACAP) was investigated in the brain, pituitary and sensory organs of the zebrafish, Danio rerio, during development, inExpand
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EGFR inhibitors and glioblastoma tumor initiating cells 1 DIFFERENT RESPONSE OF HUMAN GLIOMA TUMOR-INITIATING CELLS TO EGFR KINASE INHIBITORS
Fabrizio Griffero (1, 2), Antonio Daga (1), Daniela Marubbi (2), Maria Cristina Capra (1), Alice Melotti (1, 2), Alessandra Pattarozzi (2), Monica Gatti (2), Adriana Bajetto (2), Carola Porcile (2),Expand
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