Fabiola Mancini

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The feline AIDS model for HIV-1 treatment failed in the 1990s, due to structural features resembling protease inhibitor (PI) resistant HIV-1 variants. Widespread drug-resistance to PIs now invokes the possibility of rescuing feline immunodeficiency virus (FIV) as a model for PI treatment. We here analyzed susceptibility of FIV to second generation PIs,(More)
José R. Mediavilla, Liang Chen, Anne-Catrin Uhlemann, Blake M. Hanson, Marnie Rosenthal, Kathryn Stanak, Brian Koll, Bettina C. Fries, Donna Armellino, Mary Ellen Schilling, Don Weiss, Tara C. Smith, Franklin D. Lowy, and Barry N. Kreiswirth Author affi liations: University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA (J.R. Mediavilla,(More)
Chlamydia pneumoniae is a respiratory pathogen involved in the onset of chronic inflammatory pathologies. Dendritic cells (DC), are major players in spreading of C. pneumoniae from the lungs, a crucial step leading to disseminated infections. Less is known concerning modulation of DC functions consequent to encounter with the bacterium. In order to address(More)
The role of migratory birds in circulation tick-borne viruses needs to be better defined. In order to assess the potential role of migratory birds in exotic virus spread, we conducted a study to identify ticks collected from migratory birds in the Central Region of Italy, and performed molecular investigation for Crimea-Congo Hemorrhagic Fever (CCHFV), West(More)
Phospholipases are produced from bacterial pathogens causing very different diseases. One of the most intriguing aspects of phospholipases is their potential to interfere with cellular signaling cascades and to modulate the host-immune response. Here, we investigated the role of the innate and acquired immune responses elicited by Chlamydophila pneumoniae(More)
Treatment of feline immunodeficiency virus (FIV) infection has been hampered by the absence of a specific combination antiretroviral treatment (ART). Integrase strand transfer inhibitors (INSTIs) are emerging as a promising new drug class for HIV-1 treatment, and we evaluated the possibility of inhibiting FIV replication using INSTIs. Phylogenetic analysis(More)
1. Centers for Disease Control and Prevention. CDC immigration requirements: technical instructions for vaccination, 2007 [cited 2008 Aug 12]. Available from http://www.cdc.gov/ncidod/dq/pdf/ ti_vacc.pdf 2. Central Statistics Division. Annual statistical yearbook 2002. Saipan (Commonwealth of the Northern Mariana Islands); Department of Commerce; 2002. 3.(More)
Tick species characterization and molecular studies were performed within ornithological surveys conducted during 2010 and 2011 in the Lazio Region of central Italy. A total of 137 ticks were collected from 41 migratory birds belonging to 17 species (four partial migrants and 13 long-distance migrants). Most ticks were nymphs, with a predominance of(More)