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Objective and design:To study the involvement of all-trans retinoic acid (ATRA) in the development and maintenance of inflammatory pain. Subjects:Adult male Wistar rats and murine neuro2a and human SH-SY5Y neuroblastoma cells. Treatment:Soft-tissue inflammation was induced by the intraplantar administration of 100 μl of carrageenan λ. The oral treatment(More)
Model-Driven Development (MDD) supports the automating of code generation by performing a set of transfomations between models. This approach is currently been applied to specific domains and in particular in the web domain, and this is because web aplications have evolved with the appearance of AJAX and Web 2.0 technology, and a new breed of applications(More)
New trends in software development have proposed different interaction mechanisms for software applications. For instance, the Software as a Service (SaaS) model has defined a new delivery and access method, and installation and update processes in the user's computer are not required, software is hosted in a server and can be used over Internet instead.(More)
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