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TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation

• Alfieri Pollice, Maria Laura Sepe, +4 authors Girolama La Mantia
• Oncogene
• 2007

The p14ARF tumor suppressor is a key regulator of cellular proliferation, frequently inactivated in human cancer. The mechanisms that regulate alternative reading frame (ARF) turnover have been… (More)

Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors.

• Luigi Insabato, Ivano Amelio, +9 authors Vittorio de Franciscis
• Oncology
• 2009

OBJECTIVES Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and… (More)

A Regulatory Mechanism Involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the Control of Cell Proliferation

• Maria Laura Sepe, Luisa Festa, +8 authors Alessandra Pollice
• PloS one
• 2011

TBP-1 /Tat-Binding Protein 1 (also named Rpt-5, S6a or PSMC3) is a multifunctional protein, originally identified as a regulator of HIV-1-Tat mediated transcription. It is an AAA-ATPase component of… (More)

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