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- Toshimasa Yamauchi, Junji Kamon, +17 authors Takashi Kadowaki
- Nature Medicine
- 2002
Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad… (More)
- Yasuhiko Minokoshi, Thierry Alquier, +9 authors Barbara B. Kahn
- Nature
- 2004
Obesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2 diabetes and cardiovascular disease. The evolutionarily conserved serine/threonine kinase, AMP-activated… (More)
- D Bernard Eberle, Bronwyn D Hegarty, Pascale Bossard, Pascal Ferré, Fabienne Foufelle
- Biochimie
- 2004
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a range of enzymes required for endogenous… (More)
- Olivier Braissant, Fabienne Foufelle, Christian Scotto, Michel Dauça, Walter Wahli
- Endocrinology
- 1996
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily that can be activated by various xenobiotics and natural fatty acids. These transcription… (More)
- Pascal Ferré, Fabienne Foufelle
- Diabetes, obesity & metabolism
- 2010
Steatosis is an accumulation of triglycerides in the liver. Although an excessive availability of plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose… (More)
- M. Daval, Francine Diot-Dupuy, +6 authors Fabienne Foufelle
- The Journal of biological chemistry
- 2005
Despite its importance in terms of energy homeostasis, the role of AMP-activated protein kinase in adipose tissue remains controversial. Initial studies have described an anti-lipolytic role for… (More)
- Miriam Cnop, Fabienne Foufelle, Licio A Velloso
- Trends in molecular medicine
- 2012
The endoplasmic reticulum (ER) stress response, also commonly known as the unfolded protein response (UPR), is an adaptive response used to align ER functional capacity with demand. It is activated… (More)
- Helene L Kammoun, Hervé Chabanon, +5 authors Fabienne Foufelle
- The Journal of clinical investigation
- 2009
Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the transcription factor… (More)
- Renaud Dentin, J. P. Pegorier, +6 authors Catherine Postic
- The Journal of biological chemistry
- 2004
Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as well as for the induction of glycolytic… (More)
- Valerie A. Morrow, Fabienne Foufelle, John M.C. Connell, John R Petrie, Gwyn W. Gould, Ian P Salt
- The Journal of biological chemistry
- 2003
Recent studies have indicated that endothelial nitric-oxide synthase (eNOS) is regulated by reversible phosphorylation in intact endothelial cells. AMP-activated protein kinase (AMPK) has previously… (More)