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The selective degeneration of an axon, without the death of the parent neuron, can occur in response to injury, in a variety of metabolic, toxic, and inflammatory disorders, and during normal development. Recent evidence suggests that some forms of axon degeneration involve an active and regulated program of self-destruction rather than a passive "wasting(More)
The Jaagsiekte sheep retrovirus exJSRV and its endogenous counterpart enJSRV co-exist in sheep. exJSRV, a betaretrovirus, is the etiological agent of ovine pulmonary adenocarcinoma, and it has been demonstrated in vitro that an enJSRV Gag variant bearing the R-to-W amino acid change at position 21 was able to block exJSRV budding from the cells, providing a(More)
Ovine pulmonary adenocarcinoma (OPA) is a lung cancer strikingly similar to the pneumonic-type mixed invasive adenocarcinoma with a predominant bronchioloalveolar component in humans. Telomerase activity in OPA and the potential involvement of the kinase Akt in telomerase activation and regulation of cell proliferation were investigated. Lung tissues were(More)
EIA (Equine Infectious Anemia) is a blood-borne disease primarily transmitted by haematophagous insects or needle punctures. Other routes of transmission have been poorly explored. We evaluated the potential of EIAV (Equine Infectious Anemia Virus) to induce pulmonary lesions in naturally infected equids. Lungs from 77 EIAV seropositive horses have been(More)
It has been proposed that there is a generalized membrane defect in Huntington's disease (HD) that is expressed in non-neuronal tissue. This membrane abnormality has been linked to a glucosamine dependence of HD cells that can be demonstrated in cultured skin fibroblasts. Twenty HD, "at-risk," and normal cell lines were used in studies of growth, viability,(More)
BACKGROUND Airways progenitors may be involved in embryogenesis and lung repair. The characterization of these important populations may enable development of new therapeutics to treat acute or chronic lung disease. In this study, we aimed to establish the presence of bronchioloalveolar progenitors in ovine lungs and to characterize their potential to(More)
Huntington's disease (HD) is associated with a defect in the CNS that may involve the "glutamine cycle." There is conflicting evidence that other cell types also manifest the abnormality. Thirty HD, 20 "at-risk," and 20 normal cell lines were used in studies of viability, plating efficiency, cell growth "glutamine rescue," and tritiated thymidine and(More)
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