Fabiano Ferreira Dutra

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BACKGROUND Staphylococcus aureus is unrestrictedly found in humans and in animal species that maintain thermal homeostasis. Inadequate cleaning of processing equipment or inappropriate handling can contaminate processed food and cause severe food poisoning. Staphylococcal enterotoxin B (SEB), a potent superantigenic exotoxin, is produced by 50% of clinical(More)
Macrophage-dependent IL-1b production induces cardiac arrhythmias in diabetic mice Gustavo Monnerat1,*, Micaela L. Alarcón1,*, Luiz R. Vasconcellos2,3, Camila Hochman-Mendez1, Guilherme Brasil1, Rosana A. Bassani4, Oscar Casis5, Daniela Malan6, Leonardo H. Travassos2, Marisa Sepúlveda7, Juan Ignacio Burgos7, Martin Vila-Petroff7, Fabiano F. Dutra3, Marcelo(More)
Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia (VT). Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1β(More)
TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis. Here, we evaluated the participation of TLR2, TLR3, TLR4, and TLR9 in(More)
Chronic myeloid leukemia (CML) is rare in the pediatric population, accounting for 2-3% of childhood leukemia cases, with an annual incidence of one case per million children. The low toxicity profile of imatinib mesylate has led to its approval as a front-line therapy in children for whom interferon treatment has failed or who have relapsed after(More)
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