Fabiana Ostronoff

Learn More
Interferon regulatory factor 8 (IRF8) is a transcription factor that plays a critical role in normal hematopoiesis, such that disruption of IRF8 activity promotes leukemogenesis. We and others have identified aberrant expression of IRF8 transcripts, including novel splice variants, in acute myeloid leukemia (AML), but studies have not investigated the(More)
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CBFA) and beta (CBFB), respectively. These translocations represent two of the most common genomic abnormalities in acute myeloid leukemia (AML) patients, occurring in approximately 25% pediatric and 15% of adult with this malignancy. Both translocations are(More)
Correspondence Figure 1. Recovery of platelet counts for 5 patients with dengue hemorrhagic fever treated with high doses of intravenously administered immunoglobulin (IVIG). Day 0, day IVIG therapy initiated. Sir—During the 2002 dengue hemor-rhagic fever (DHF) outbreak in Brazil, we treated 5 patients in Recife with DHF. The patients were white women aged(More)
  • 1