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The wide utility of rabbits as models of human diseases
TLDR
This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases.
Maximum-likelihood approaches reveal signatures of positive selection in IL genes in mammals
TLDR
Most mammalian ILs have sites evolving under positive selection, which may be explained by the multitude of biological processes in which ILs are enrolled.
Convergent loss of the necroptosis pathway in disparate mammalian lineages shapes virus countermeasures
TLDR
This study provides the first comprehensive picture of the molecular evolution of necroptosis in mammals and highlights a co-evolutionary relationship between poxviruses and their hosts, emphasizing the role of host adaptation in shaping virus evolution.
Evolutionary Insights into IL17A in Lagomorphs
TLDR
This study gives further support to the hypothesis that European rabbit might be a more suitable animal model for studies on human IL17, and observes that this protein is highly conserved between these species, with a similarity of 97–99% in leporids and ~88% between leporid and American pika.
An overview of the lagomorph immune system and its genetic diversity
TLDR
The genetic diversity of the European rabbit immune system is discussed, the most recent advances in identifying interleukins, chemokines and chemokine receptors, Toll-like receptors, antiviral proteins, and the genes encoding fucosyltransferases that are utilized by rabbit hemorrhagic disease virus are reviewed.
Analysis of substitution rates showed that TLR5 is evolving at different rates among mammalian groups
TLDR
The results show that the TLR5 substitution rate is not uniform among mammals, in fact, among the different mammal groups studied, the Lagomorpha, Rodentia, Carnivora and Chiroptera are evolving faster.
Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
TLDR
Overall, these ILs are conserved between lagomorphs, including in their exon/intron structure, and sequences of human and European rabbit are more closely related than between human and mouse or European rabbit and mouse.
Convergent evolution of IL-6 in two leporids (Oryctolagus and Pentalagus) originated an extended protein
TLDR
The results indicate that the IL-6 extension in European rabbits belonging to the subspecies Oryctolagus cuniculus algirus subspecies and five additional lagomorphs’ genera occurred by two independent events: one occurred between 2 and 8 million years ago in the ancestral of the OryCTolagus subspecies, and the other occurred in a Pentalagus ancestral at a maximum of 9 million ago.
Author Correction: The wide utility of rabbits as models of human diseases
This article was originally published under a CC BY-NC-SA License, but has now been made available under a CC BY 4.0 License.
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