Fabiana Bifulco

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Chronic obstructive pulmonary disease (COPD) and asthma are both characterized by heterogeneous chronic airway inflammation and obstruction as well as oxidative stress (OS). However, it is unknown whether OS occurs in early disease and how to best assess its presence. Plasma OS markers (TBARS, PSH, taurine, GSH, ergothioneine and paraoxonase 1 activity) and(More)
BACKGROUND Elevated plasma concentrations of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) have been observed in respiratory conditions such as asthma and cystic fibrosis. Since oxidative stress has been shown to increase the activity of arginine methylating enzymes, hence increased ADMA synthesis, and to reduce(More)
EDITOR: A 49-yr-old female suddenly experienced intense lower neck pain irradiating to her right arm and trunk. Within a few minutes, she developed rightsided weakness in her arm and leg. She had recently been diagnosed with hypertension but was on no treatment. On admission to the emergency hospital, she was afebrile with high systolic (190– 210 mmHg) and(More)
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