Fabian Zimmermann

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Determinations of the pKa-values by the spectrophotometric method indicate significant differences in the acidic behaviour between piroxicam and tenoxicam on the one hand and isoxicam on the other. In the case of the first named 2-pyridyl-substituted substances the two measurable and due to the UV-shift individually assignable pKa-values might be explained(More)
BACKGROUND The pollen-food syndrome (PFS) is an association of food allergies to fruits, nuts, and vegetables in patients with pollen allergy. Mal d 1, the major apple allergen, is one of the most commonly associated food allergens for birch pollen-allergic patients suffering from PFS. Although the reactions are due to cross-reactive IgE antibodies(More)
The present pharmacological test results characterize soquinolol (5-[3-tertiary butylamino-2-hydroxypropoxy]-2-formyl-1,2,3,4- tetrahydroisoquinoline mucate, We 704, Sertum) as a highly potent non-subtype-selective beta-adrenergic receptor blocker, which is devoid of any intrinsic sympathomimetic activity. Its localanaesthetic activity (membrane stabilizing(More)
Aims Iron deficiency (ID) is associated with adverse outcomes in heart failure (HF) but the underlying mechanisms are incompletely understood. Intracellular iron availability is secured by two mRNA-binding iron-regulatory proteins (IRPs), IRP1 and IRP2. We generated mice with a cardiomyocyte-targeted deletion of Irp1 and Irp2 to explore the functional(More)
Two experiments were carried out to determine the period of time for a) the decrease of the load resulting in rupture of excised dorsal skin strips of the rat induced by daily oral treatment with D-beta, beta-dimethylcysteine (D-penicillamine, Metalcaptase) and b) the effect produced by D-penicillamine treatment to subside after discontinuation of the(More)
The question of a D-penicillamine maintenance dose was tested by the load resulting in rupture of excised strips of dorsal skin of male albino rats. The reduction in load resulting in rupture (-48.5 per cent) obtained by 14 days of treatment with 320 mg/kg/day orally can be maintained completely over a treatment period of 28 days by daily administration of(More)