Fabian Kirchhoff

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OBJECTIVE Glucocorticoids play a major role in the consolidation and retrieval of traumatic information. They act through the glucocorticoid receptor, for which, in humans, several polymorphisms have been described. In particular, the BclI single-nucleotide polymorphism is associated with hypersensitivity to glucocorticoids and with susceptibility to(More)
BACKGROUND LC-MS/MS is an almost universal technology for the quantification of small molecules in human sample materials. The widespread use of this technology in laboratory medicine is so far limited mainly by the extensive occupation of highly trained personnel which is required for method implementation and application. Furthermore, robustness of(More)
AIM Music might benefit preterm infants in stressful, intensive care environments. However, data on stress level indicators, determined by salivary cortisol levels, are scarce. We evaluated the effect of live harp music on the stress level indicators of preterm infants in a neonatal intensive care unit (NICU). METHODS We exposed 20 stable preterm infants(More)
BACKGROUND The goal of this study was to develop and to validate an improved isotope-dilution-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of methylmalonic acid (MMA) in urine. METHODS A previously described sample preparation protocol requires two solvent extraction steps, including evaporation. The first(More)
OBJECTIVES Only unbound serum cortisol is bioactive and protein binding of cortisol is highly variable. Thus, the quantification of free serum cortisol (FSC) is of superior biological relevance compared to total serum cortisol quantification. Consequently, the development of automated routine tests for FSC for endocrine testing is desirable - along the(More)
Schlafstörungen und schlafassoziierte Störungen stellen im Kindesalter ein häufiges Problem dar. Die Zuweisung an ein pädiatrisches Schlaflabor wie auch die Diagnostik und Einleitung von Therapiemaßnahmen werden uneinheitlich gehandhabt. In diesem Konsensuspapier werden daher Empfehlungen formuliert, wann pädiatrische Patienten einem Kinderschlaflabor(More)
BACKGROUND Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. METHODS Following protein precipitation, on-line solid(More)
Die adenotonsilläre Hyperplasie (ATH; vergrößerte Adenoide und Tonsillen) kann zu ausgeprägten Atmungsstörungen wie behinderte Nasenatmung, behinderte Mundatmung, habituellem Schnarchen und obstruktiver Schlafapnoe führen und sollte dann auch behandelt werden. Bisher wurde meist eine Adenotomie bzw. Adenotonsillektomie als primäre Therapie empfohlen. Nun(More)