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Article numérisé dans le cadre du programme Numérisation de documents anciens mathématiques ABSTRACT-We show the existence of a solution to the total differential inclusion: assuming that the convexified problem admits a smooth solution. The proof relies on a Baire category argument. Some examples are given, showing that in general our hypotheses cannot be… (More)
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ. In response to stimulation, LATS1/2 phosphorylate and inhibit YAP/TAZ, the main effectors of the Hippo pathway.… (More)
In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.