Faazal Rehman

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We reviewed 63 cases of cytologically confirmed leptomeningeal metastases (LM). 31 (49%) had solid tumors 17 (27%) had leukemia and 15 (24%) had lymphoma. The most common presenting symptom was pain (76%) with radicular discomfort (58%), headache (32%), neck or back pain (17%). The predominant neurological signs were mental status abnormalities (49%),(More)
In research conducted over the past 20 years, we have observed abnormal trace-metal concentrations, including elevated serum copper and depressed plasma zinc, in blood samples collected from violence-prone individuals. The purpose of the study reported here was to test the validity of our observation that assaultive young males have elevated blood(More)
The synthetic retinoid N-(4-hydroxphenyl) retinamide (4HPR) has manifold actions, which may contribute to its chemopreventive effects on breast cancer cell growth and progression. A role for ceramide as a stress-response signal is investigated here during the cytotoxic action of 4HPR in MCF-7 cells. N-(4-hydroxphenyl) retinamide induced a dose-dependent(More)
Purpose. The incidence of liver neoplasms is rising in USA. The purpose of this study was to determine metabolic profiles of liver tissue during early cancer development. Methods. We used the rabbit VX2 model of liver tumors (LT) and a control group consisting of sham animals implanted with Gelfoam into their livers (LG). After two weeks from implantation,(More)
  • S R S S Naqvi, F Naqvi, F Rehman, R Naghman, A Tariq, Zainab
  • 2013
We propose a scalable architecture for a Discrete Cosine Transform (DCT) computation engine based on S ingle Instruction stream and Multiple Data stream (S IMD)-Array Processors. Each pixel of an input matrix is distributed across a 4-way connected Processing Element (PE); and a frame comprises several such PEs making it possible to compute as many pixels(More)
Melanin-concentrating hormone (MCH) is involved in the regulation of food intake and has recently been associated with alcohol-related behaviors. Blockade of MCH-1 receptors (MCH1-Rs) attenuates operant alcohol self-administration and decreases cue-induced reinstatement, but the mechanism through which the MCH1-R influences these behaviors remains unknown.(More)
BACKGROUND Reward and energy homeostasis are both regulated by a network of hypothalamic neuropeptide systems. The melanin-concentrating hormone (MCH) and its MCH-1 receptor (MCH1-R) modulate alcohol intake, but it remains unknown to what extent this reflects actions on energy balance or reward. Here, we evaluated the MCH1-R in regulation of caloric intake(More)
  • E Barbier, Al Johnstone, Bb Khomtchouk, Jd Tapocik, C Pitcairn, F Rehman +9 others
  • 2016
Epigenetic processes have been implicated in the pathophysiology of alcohol dependence, but the specific molecular mechanisms mediating dependence-induced neuroadaptations remain largely unknown. Here, we found that a history of alcohol dependence persistently decreased the expression of Prdm2, a histone methyltransferase that monomethylates histone 3 at(More)
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