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Localization studies and genetic evidence have implicated cartilage-derived morphogenetic proteins-1, -2 (CDMP-1 and CDMP-2), and osteogenic protein-1 (OP-1) in the osteochondrogenic differentiation of mesenchymal progenitor cells during embryonic development and in postnatal life. Based on their expression pattern and the evidence that periosteum contains(More)
Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis SIR, Osteoarthritis and osteoporosis are disabling diseases in the elderly. Clinical observations suggest an inverse relationship between these disorders (for review see [1]). This hypothesis is still controversial and no(More)
Progression of ankylosis in patients with ankylosing spondylitis is highly variable. This suggests that ankylosis is at least partially due to genetic factors. We used the ankylosing enthesits model in DBA/1 mice to search for associated genes. Male DBA/1 were crossed with female BALB/c mice. Male F2 mice from different litters were studied by(More)
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