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This study evaluated the effects of magnesium supplementation on the development of hypertension in spontaneously hypertensive rats (SHR) and assesses the actions of magnesium on extracellular and intracellular Ca2+, Na+, and K+ status. Ten-week-old SHR (n = 72) and Wistar-Kyoto rats (WKY) (n = 60) were divided into four groups: WKY, Mg-WKY (WKY receiving(More)
Increased sodium ingestion is regarded as a possible aetiological factor in chronic systemic hypertension. In order to assess dietary intake, the 24-hour urinary sodium and potassium excretions were measured in 71 Black (group 1) and 34 White (group 2) normotensive urban male factory workers, all of whom were aged between 30 and 50 years. The 24-hour(More)
Many studies have suggested that there is an association between the sodium status, plasma renin and aldosterone profile and essential hypertension. We measured serum, urine and red blood cell (RBC) sodium and potassium, plasma renin and aldosterone levels in normotensive Whites, normotensive Blacks, mildly hypertensive Blacks, severely hypertensive Blacks(More)
OBJECTIVE To determine whether cellular cation concentrations and cell membrane ATPase activity are altered in patients with malignant hypertension. DESIGN Sixteen black patients with malignant hypertension were studied and compared with age- and sex-matched essential hypertensive and normotensive subjects. Calcium, magnesium, sodium and potassium(More)
Serum magnesium, calcium, sodium and potassium, and erythrocyte magnesium, sodium and potassium levels were measured in a selected group of 296 urbanised black male labourers in Johannesburg. Of these, 214 subjects were normotensive and 82 were hypertensive. The aim of the study was to examine the relationship between serum and erythrocyte electrolytes,(More)
Alterations in intracellular cation metabolism have been implicated in the pathophysiology of essential hypertension. Total magnesium, calcium, sodium and potassium levels were studied in serum erythrocytes and platelets, from 154 subjects (76 hypertensive and 78 normotensives; 104 blacks and 50 whites). In the combined black and white hypertensive group,(More)
Arsine (arsineuretted hydrogen, AsH3) was first identified in 1775. It is a colourless, non-irritant gas that smells like garlic. After the initial demonstration of its toxicity in 1815, 454 cases of poisoning had been documented by 1974.' To date, a further 16 cases have been described,2 ` including one with permanent renal damage.6 Many cases probably go(More)
Autopsy material was examined from cases diagnosed as malignant nephrosclerosis in the years 1956-1961, a period when adequate antihypertensive therapy had not yet become available, a second group of malignant nephrosclerosis from the years 1970-1980, an era during which effective antihypertensive therapy was available, and a third group of essential benign(More)
Characteristic skeletal changes of dialysis bone disease associated with multiple fractures were found in ten patients on prolonged regular (high aluminium) haemodialysis. A subsequent prospective investigation with serial radiography demonstrated healing approximately twelve months after a changed treatment regime. The treatment used was deionized or(More)