FHipDvorakandRoman Bartak

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The effects of calcitonin gene-related peptide (CGRP) on the transient outward current (Ito) and the L-type calcium current (ICa,L) were investigated in isolated rat ventricular cardiomyocytes using the whole-cell, patch-clamp technique. CGRP influenced neither the amplitude nor the time course of ICa,L. On the other hand, at all membrane potentials at(More)
Using the glass microelectrodes techniques, we analysed the causes of the shortening of the ventricular myocardial action potentials (AP) of albino rats during postnatal development. Delayed outward currents were blocked with tetraethylammonium (TEA) in 20 mmol.l-1 concentration. TEA led to prolongation of action potentials and to accentuation of frequency(More)
The effect of paired stimulation on the action potentials of the working ventricular myocardium of newborn and adult rabbits was studied with the aim of elucidating the postnatal development of electrogenesis in cardiac cells. After a 2 minutes' rest pause we applied two identical rectangular electric pulses (duration 0.1-1 ms, voltage double the(More)
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