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The role of iron in brain ageing and neurodegenerative disorders
SUMMARY In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism ofExpand
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.
In this study, a comparative analysis of metal-related neuronal vulnerability was performed in two brainstem nuclei, the locus coeruleus (LC) and substantia nigra (SN), known targets of theExpand
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
Subsets of rodent neurons are reported to express major histocompatibilty complex class I (MHC-I), but such expression has not been reported in normal adult human neurons. Here we provide evidenceExpand
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
HIGHLIGHTSIn this review the multiways interactions/modulations between iron, dopamine oxidation, neuromelanin and their role in brain are discussed.The relationship between iron and dopamineExpand
Protective and toxic roles of dopamine in Parkinson's disease
The molecular mechanisms causing the loss of dopaminergic neurons containing neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson's disease are still unknown. TheExpand
Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics
Neuromelanin accumulates in dopaminergic neurons during normal aging, and in Parkinson's disease, neurons with this pigment are those that selectively degenerate. Intraneuronal neuromelanin couldExpand
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
The most striking morphologic change in neurons during normal aging is the accumulation of autophagic vacuoles filled with lipofuscin or neuromelanin pigments. These organelles are similar to thoseExpand
Neuromelanin of the Human Substantia Nigra: An Update
Dopaminergic neurons of the substantia nigra selectively degenerate over the course of Parkinson’s disease. These neurons are also the most heavily pigmented cells of the brain, accumulating the darkExpand
Engineered nanoparticles. How brain friendly is this new guest?
In the last 30 years, the use of engineered nanoparticles (NPs) has progressively increased in many industrial and medical applications. In therapy, NPs may allow more effective cellular andExpand
Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability
Summary.In this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (LC) and substantia nigra (SN), known targets of Parkinson’s Disease (PD) and relatedExpand
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