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Inhibitors of nitric oxide production from hops (Humulus lupulus L.).
- F. Zhao, H. Nozawa, Akihiro Daikonnya, K. Kondo, S. Kitanaka
- BiologyBiological & pharmaceutical bulletin
The inhibitory effect of extracts from Humulus lupulus L. on both the production of NO and the expression of inducible NO synthase (iNOS) in mouse macrophage RAW 2647 cells was investigated.
Characterization and Online Detection of Surfactin Isomers Based on HPLC-MSn Analyses and Their Inhibitory Effects on the Overproduction of Nitric Oxide and the Release of TNF-α and IL-6 in…
It was revealed that the surfactin isomers showed strong inhibitory properties on the overproduction of nitric oxide and the release of IL-6 on LPS-induced murine macrophage cell RAW264, which will be very helpful for the development of this novel kind of natural product as new anti-inflammatory agents.
Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: translocation of nuclear factor-κB as potential target.
Curcumin and its major metabolites inhibited the LPS‑induced inflammatory response via the mechanism of inhibiting NF‑κB translocation to the nucleus.
Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus).
- F. Zhao, Y. Watanabe, H. Nozawa, Akihiro Daikonnya, K. Kondo, S. Kitanaka
- ChemistryJournal of natural products
The ethyl acetate soluble fraction of hops (Humulus lupulus) showed potent inhibitory activity on the production of nitric oxide (NO) induced by a combination of LPS and IFN-gamma. Four known…
The protective effect of hydroxyl-substituted Schiff bases on the radical-induced oxidation of DNA
The protective effects of 18 hydroxyl-substituted Schiff bases (SchOHs) on the oxidative damage of naked DNA induced by 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) were reported, in which…
Annexin 1 exerts anti-nociceptive effects after peripheral inflammatory pain through formyl-peptide-receptor-like 1 in rat dorsal root ganglion.
Endogenous ANXA1 expression at the DRG level is involved in CFA-induced inflammatory pain, and i.t. Anxa1 20 µg µl(-1) produces its anti-nociceptive effect through FPR2/ALX.
Bidesmoside triterpenoid glycosides from Stauntonia chinensis and relationship to anti-inflammation.
Dietary supplement of isohumulones inhibits the formation of aberrant crypt foci with a concomitant decrease in prostaglandin E2 level in rat colon.
Observations suggest that isohumulones show chemopreventive effects on ACF formation in rat colon by inhibiting the production of PGE2.
[Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin].
- W. Yu, Wei-juan Kan, P. Yu, Min-min Li, Jisoo Song, F. Zhao
- Biology, MedicineZhongguo Zhong yao za zhi = Zhongguo zhongyao…
- 1 September 2012
Dihydroartemisinin inhibits macrophages from releasing inflammatory factors TNF-alpha and IL-6 and inflammatory mediators NO by down-regulating iNOS protein, which may help dihydroart Artemisinin to show its anti-inflammatory effect through metabolism.