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Effect of BDNF Val66Met Polymorphism on Digital Working Memory and Spatial Localization in a Healthy Chinese Han Population
Cognitive abilities are complex human traits influenced by genetic factors. Brain-derived neurotrophic factor (BDNF), a unique polypeptide growth factor, has an influence on the differentiation andExpand
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An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population
Cathechol-O-methyltransferase (COMT) regulates the amount of dopamine in the prefrontal cortex (PFC). Substantial studies indicate a close relationship between COMT and several human psychoticExpand
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Positive association of the FTSJ1 gene polymorphisms with nonsyndromic X-linked mental retardation in young Chinese male subjects
AbstractTo investigate the possible genetic association of nonsyndromic X-linked mental retardation (NS-XLMR) with FTSJ1 gene polymorphisms, a case–control association study was performed focusing onExpand
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Variations in 5-HT2A influence spatial cognitive abilities and working memory.
BACKGROUND 5-hydroxytryptamine receptor 2A (5-HT2A) participates in diverse psychiatric disorders by regulating the activity of serotonin. Some previous studies have also suggested that the receptorExpand
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  • Open Access
An Association Study on the Polymorphisms of Dopaminergic Genes with Working Memory in a Healthy Chinese Han Population
Working memory (WM) is a highly heritable cognitive trait that is involved in many higher-level cognitive functions. In the past few years, much evidence has indicated that the reduction of dopamineExpand
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Psoriasis is one of the most common skin diseases in the world. In 1984, a cooperative epidemiologic study of psoriasis, the first on a large scale with a uniform survey method and criteria, wasExpand
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Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba Mountains Region of China
Objective Neuroligin-4 is essential for proper brain function. Some studies indicate a close relationship between neuroligin-4 and several human psychiatric conditions. Methods The case–controlExpand
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A study on the correlation between IL1RAPL1 and human cognitive ability
This study aimed to investigate the effects of IL1RAPL1 on the human cognitive ability. Four genetic marker sites, i.e., DXS1218, DXS9896, rs6526806 and rs12847959 on IL1RAPL1 were genotyped in 332Expand
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Variants in COMT and DBH Influence on Response Inhibition Ability in Chinese Han Females
Catechol-O-methyltransferase (COMT) and dopamine-beta hydroxylase (DBH) are key enzymes to breakdown dopamine. Some previous studies have indicated that val158met in COMT and 19 bp insertion/deletionExpand
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