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Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling.
- L. Vincent, P. Kermani, +11 authors S. Rafii
- Biology, Medicine
- The Journal of clinical investigation
- 1 November 2005
The molecular and cellular pathways that support the maintenance and stability of tumor neovessels are not well defined. The efficacy of microtubule-disrupting agents, such as combretastatin A4… Expand
Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry
To define the cell populations in rheumatoid arthritis (RA) driving joint inflammation, we applied single-cell RNA-seq (scRNA-seq), mass cytometry, bulk RNA-seq, and flow cytometry to sorted T cells,… Expand
Effects of Locomotion Mode Recognition Errors on Volitional Control of Powered Above-Knee Prostheses
Recent studies have reported various methods that recognize amputees' intent regarding locomotion modes, which is potentially useful for volitional control of powered artificial legs. However,… Expand
Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes.
The imaging of sentinel lymph nodes (SLNs), the first defense against primary tumor metastasis, has been considered as an important strategy for noninvasive tracking tumor metastasis in clinics. In… Expand
Preclinical Lymphatic Imaging
Noninvasive in vivo imaging of lymphatic vessels and lymphatic nodes is expected to fulfill the purpose of analyzing lymphatic vessels and their function, understanding molecular mechanisms of… Expand
A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation
MYC is a key player in tumor development, but unfortunately no specific MYC-targeting drugs are clinically available. MYC is strictly dependent on heterodimerization with MAX for transcription… Expand
Differentiation of Reactive and Tumor Metastatic Lymph Nodes with Diffusion-weighted and SPIO-Enhanced MRI
- F. Zhang, Lei Zhu, Xinglu Huang, G. Niu, X. Chen
- Molecular Imaging and Biology
- 1 February 2013
ObjectivesDetermination of lymphatic metastasis is of great importance for both treatment planning and patient prognosis. We aim to distinguish tumor metastatic lymph nodes (TLNs) and reactive lymph… Expand
Phase separation induced molecular fractionation of gum arabic--sugar beet pectin systems.
This paper investigates the phase separation and phase separation-induced fractionation of gum arabic (GA)/sugar beet pectin (SBP) mixed solutions. A phase diagram, including cloud and binodal… Expand
Silk-functionalized titanium surfaces for enhancing osteoblast functions and reducing bacterial adhesion.
- F. Zhang, Z. Zhang, Xiu-lin Zhu, E. Kang, K. Neoh
- Materials Science, Medicine
- 1 December 2008
It would be ideal to have implants which can simultaneously inhibit bacterial adhesion and promote osteoblast functions. In this work, titanium surfaces were modified with poly(methacrylic acid)… Expand
Nanoscale effects in dendrimer-mediated targeting of neuroinflammation.
Neuroinflammation, mediated by activated microglia and astrocytes, plays a key role in the pathogenesis of many neurological disorders. Systemically-administered dendrimers target neuroinflammation… Expand