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The bHLH genes GLABRA3 (GL3) andENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root
TLDR
A model in which GL3 and EGL3 act together with WER in the N cell position to promote the non-hair cell fate, whereas they interact with the incomplete MYB protein CPC in the H position, which blocks theNon-hair pathway and leads to the hair cell fate is suggested.
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
TLDR
It is concluded that GLP-1 improves endothelial dysfunction but not insulin resistance in type 2 diabetic patients with coronary heart disease and adds yet another salutary property of the peptide useful in diabetes treatment.
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.
We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded breaks (DSBs).
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
TLDR
A genome-wide association study of type-2 diabetes in individuals of South Asian ancestry provides additional insight into mechanisms underlying T2D and shows the potential for new discovery from genetic association studies in South Asians.
GL 3 Encodes a bHLH Protein That Regulates Trichome Development in Arabidopsis Through Interaction With GL 1 and TTG 1 C .
Arabidopsis trichome development and differentiation is a well-studied model for plant cell-fate determination and morphogenesis. Mutations in TRANSPARENT TESTA GLABRA1 (TTG1) result in several
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.
TLDR
It is shown that BACH1 is both a DNA-dependent ATPase and a 5'-to-3' DNA helicase, and in two patients with early-onset breast cancer who carry distinct germline Bach1 coding sequence changes, the resulting proteins are defective in helicase activity, indicating that these sequence changes disrupt protein function.
A Triad of Subunits from the Gal11/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p
TLDR
The med2Δ mutation impairs the recruitment of TATA binding protein (TBP) and RNA polymerase II to the promoter and the induction of transcription at ARG1, demonstrating the importance of the tail domain for activation by Gcn4p in vivo.
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii.
TLDR
Structural codes and architecture of the complete proteasome are revealed, potential substrate-binding sites are identified, and unexpected asymmetry is uncovered in the RP of archaea and eukaryotes.
Genetic landscape of esophageal squamous cell carcinoma
TLDR
The mutational profile of ESCC closely resembles those of squamous cell carcinomas of other tissues but differs from that of esophageal adenocarcinoma, with mutations in epigenetic modulators with prognostic and potentially therapeutic implications highlighted.
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.
  • Y. Li, F. Zhang, +16 authors Xuri Li
  • Biology, Medicine
    The Journal of clinical investigation
  • 3 March 2008
TLDR
It is shown that VEGF-B inhibited the expression of genes encoding the proapoptotic BH3-only proteins and other apoptosis- and cell death-related proteins, including p53 and members of the caspase family, via activation of VEGFR-1, suggesting that the first member of the V EGF family that has a potent antiAPoptotic effect while lacking a general angiogenic activity.
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