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Persistent sulfate formation from London Fog to Chinese haze
TLDR
The results explain the outstanding sulfur problem during the historic London Fog formation and elucidate the chemical mechanism of severe haze in China, and suggest that effective haze mitigation is achievable by intervening in the sulfate formation process with NH3 and NO2 emission control measures. Expand
A bZIP transcription factor, OsABI5, is involved in rice fertility and stress tolerance
TLDR
Complementation analysis revealed that the expression of OsABI5 driven by the 35S promoter could rescue ABA-insensitivity of abi-1 during seed germination and result in hypersensitivity to ABA. Expand
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
TLDR
It is shown that SIRT1 is downregulated in insulin-resistant cells and tissues and that knockdown or inhibition of Sirt1 induces insulin resistance, and that increased expression of SIRT 1 improved insulin sensitivity, especially under insulin- resistant conditions. Expand
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
TLDR
Analysis of TCC by whole-genome and whole-exome sequencing provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer. Expand
Cost-related medication nonadherence and spending on basic needs following implementation of Medicare Part D.
TLDR
There was evidence for a small but significant overall decrease in CRN and forgoing basic needs following Part D implementation, and no net decrease inCRN after Part D was observed among the sickest beneficiaries, who continued to experience higher rates of CRN. Expand
Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning.
TLDR
It is document successful reconstitution of immune function in a child with the adenosine deaminase (ADA)-deficient form of severe combined immunodeficiency (SCID) following hematopoietic stem cell (HSC) gene therapy. Expand
Disappearance of antibodies to SARS-associated coronavirus after recovery.
TLDR
It is shown that IgG and neutralizing antibodies against coronavirus associated with the severe acute respiratory syndrome (SARS) may persist, in spite of a de nova vaccination campaign. Expand
Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase–Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction
TLDR
Two new studies provide clinical support for treatment options that may allow SCID patients without matched donors to live relatively normal lives as well and support the development of new safer and more efficient vectors for this and other kinds of gene therapy. Expand
Changes in spinal cord regenerative ability through phylogenesis and development: Lessons to be learnt
TLDR
A better understanding of the mechanisms underlying spontaneous regeneration of the spinal cord in vivo in amphibians and in the chick embryo will help to devise strategies for restoring function to damaged or diseased nervous tissues in mammals. Expand
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
TLDR
The data reveal that PERK-dependent signaling is used during both tumor initiation and expansion to maintain redox homeostasis, thereby facilitating tumor growth. Expand
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