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Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing.
In vivo exercise interventions differentially regulate serum COMP concentrations and knee cartilage deformations and there is a significant correlation between changes in serum COMP (%) and in cartilage volume after the drop landing intervention, but not after running. Expand
Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of articular primary chondrocytes.
- F. Zaucke, R. Dinser, P. Maurer, M. Paulsson
- Chemistry, Medicine
- The Biochemical journal
- 15 August 2001
The results demonstrate that the potential for redifferentiation decreases with increasing length of monolayer culture and show that the alginate bead system represents an attractive in vitro model to study the chondrocyte de- and re-differentiation processes, as well as extracellular matrix assembly. Expand
Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition
- C. Widmer, Jan M. Gebauer, +5 authors U. Baumann
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 30 July 2012
The structures explain the stabilization of the triple helix as well as the inhibition of collagen-bundle formation by Hsp47 and propose a pH-dependent substrate release mechanism based on a cluster of histidine residues. Expand
Interleukin-1β signaling in osteoarthritis - chondrocytes in focus.
Interleukin-1 signaling (IL-1) plays a central role and its effects on the different cell types involved in OA are discussed in this review with a special focus on the chondrocyte. Expand
Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.
- F. Zaucke, Joana M Boehnlein, +13 authors M. Wolf
- Medicine, Biology
- Human molecular genetics
- 15 May 2010
It is demonstrated that UMOD is expressed in the primary cilia of renal tubules, using immunofluorescent studies in human kidney biopsy samples and this data adds UMOD to the group of proteins expressed inPrimary cilia, where mutations of the gene lead to cystic kidney disease. Expand
Structural variability of BM-40/SPARC/osteonectin glycosylation: implications for collagen affinity.
BM-40 carrying high-mannose structures binds collagen I with higher affinity, suggesting that differentially glycosylated forms may have different functional roles in vivo. Expand
Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review
It is discussed that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response. Expand
Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations.
- M. Schmitz, A. Niehoff, N. Miosge, N. Smyth, M. Paulsson, F. Zaucke
- Chemistry, Medicine
- Matrix biology : journal of the International…
- 1 March 2008
Biochemical characterization of cartilage tissue demonstrated that transgenic and endogenous COMP subunits were able to form mixed, pentameric molecules in vivo, and Mutant COMP was more difficult to extract than the wildtype protein, suggesting an altered anchorage within the matrix. Expand
Adaptation of mechanical, morphological, and biochemical properties of the rat growth plate to dose-dependent voluntary exercise.
Results clearly demonstrate adaptations of morphology and biochemical parameters to the dose of running exercise, which do not result in significant differences in mechanical properties or bone length between the UE, LE, and CON groups. Expand
The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect.
Haplotype analysis showed cosegragation with the phenotype in all eight affected individuals indicating that the C744G mutation may be due to a founder effect, and a novel T229G (Cys77Gly) mutation in two affecteds of one kindred is described. Expand