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Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.
The most efficient routes for the synthesis of FCE 22101, a penem antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891,
Reactivity parameters of the metal assisted 1,2-cleavage of penicillins
A straigtforward and smooth conversion of penicillins into 1,2-secopenicillanates is described. The thiazolidine ring opening is brought about by the co-operative effect of strong non-nucleophilic
Dual-action penems.
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