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Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy.
TLDR
A 160-member library of tricyclic sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy.
2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl methanesulfonate
TLDR
The asymmetric unit of the title compound, C7H11N3O5S, contains two independent molecules with virtually identical conformations, and in the crystal, molecules are linked to form a three-dimensional framework by C—H⋯O and C–H–N hydrogen bonds.
Intramolecular monomer-on-monomer (MoM) Mitsunobu cyclization for the synthesis of benzofused thiadiazepine-dioxides.
The utilization of a monomer-on-monomer (MoM) intramolecular Mitsunobu cyclization reaction employing norbornenyl-tagged (Nb-tagged) reagents is reported for the synthesis of benzofused
Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.
TLDR
A facile one-pot, sequential strategy employing in situ Huisgen cycloaddition post-double aza-Michael has been accomplished, and is applicable to library synthesis.
Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.
TLDR
A suite of soluble OTP(n) reagents for facile (triazolyl)methylation of 10 MACOS-derived sultam scaffolds in purification-free process for parallel synthesis of small molecule collections for HTS.
Synthesis of 2,3-disubstituted pyrazines and quinoxalines by Heck cross-coupling reactions of 2,3-dichloropyrazine and 2,3-dichloroquinoxaline. Influence of the temperature on the product distribution
Heck cross-coupling reactions of 2,3-dichloropyrazine provide a convenient approach to 2,3-dialkenyl-, 2-alkenyl-3-alkyl-, and 2,3-dialkylpyrazines depending on the reaction conditions.
"Click"-capture, ring-opening metathesis polymerization (ROMP), release: facile triazolation utilizing ROMP-derived oligomeric phosphates.
TLDR
Utilizing a "Click"-capture, ROMP, release protocol, the efficient and purification-free, direct triazolation of N, O, and S-nucleophilic species was successfully achieved.
O-Alkylation of Menthone Oxime: Synthesis and 13C NMR Studies of a Series of Novel Oxime Ethers
A series of novel menthone oxime ethers were synthesized in three steps starting from (–)-menthol. Analysis of the 13C NMR chemical shift differences between α carbons of oxime derivatives (O-alkyl
A Pentacyclic Triterpene from Litchi chinensis
The aerial parts of Litchi chinensis Gaertn. (Sapindaceae) yielded one new pentacyclic triterpene [lup-12, 20(29) diene-3, 27-diol], along with the known compounds betulinic acid, lupeol, betulin,
5-(Prop-2-ynyl)-5H-dibenzo[b,f]azepine
TLDR
The asymmetric unit of the title compound, C17H13N, contains two independent butterfly-shaped molecules that adopt a boat conformation and the dihedral angles between the benzene rings in the two molecules are 46 (11)°.
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