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Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury.
The effects of 6,7,8, 9-tetrahydro-2-methyl-5H-cyclohepta[b]pyridine-3-carbonylguanidine maleate (TY-12533) on myocardial ischemia/reperfusion injury were evaluated in rats. Inhibitory effects ofExpand
Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog
TLDR
The results suggest that the vasorelaxant effect of FK409, like that of nitroglycerin, is due to activation of soluble guanylate cyclase and a resultant increase in intracellular cyclic GMP. Expand
A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart
TLDR
It is indicated that both nicorandil and SG-209 act as K-channel openers in coronary resistance vessels and in ventricular myocardium, and that the nitroxyl and the acetoxyl group at C2 of the parent structure of nicor andil and its congeners play a pivotal role in making these compounds act asK- channel openers. Expand
Specific but differential antagonism by glibenclamide of the vasodepressor effects of cromakalim and nicorandil in spinally‐anaesthetized dogs
TLDR
The results suggest that the vasodepressor action of cromakalim is due predominantly to potassium channelOpening, but that of nicorandil involves not only potassium channel opening but its action as a nitrate. Expand
Vasodepressor mechanisms of 2-(1-octynyl)-adenosine (YT-146), a selective adenosine A2 receptor agonist, involve the opening of glibenclamide-sensitive K+ channels.
TLDR
The results suggest that the vasodepressor effect of YT-146 involves two mechanisms following stimulation of adenosine A2 receptors; one is probably a cyclic AMP-dependent mechanism and the other is the opening of glibenclamide-sensitive K+ channels. Expand
The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries
TLDR
The results indicate that the group at C2 of the parent structure of nicorandil and its congeners, i.e., N-ethylnicotinamide determines not only the vasodilator potency but the vasODilator mechanism of action of the compound. Expand
Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism
TLDR
The results indicate that the effect of nicorandil in increasing coronary blood flow, like that of cromakalim, is predominantly due to its mechanism of action as a K-channel opener. Expand
TY-12533, a novel Na(+)/H(+) exchange inhibitor, prevents myocardial stunning in dogs.
TLDR
Results indicate that TY-12533, even when administered during ischemia, could prevent myocardial stunning without affecting myocardia dysfunction or acidosis induced by brief ischemIA. Expand
Amelioration of Ischemia/Reperfusion-Induced Myocardial Infarction by the 2-Alkynyladenosine Derivative 2-Octynyladenosine (YT-146)
TLDR
YT-146 at both doses elicited a dose-dependent increase in acute hyperemic coronary flow immediately after reperfusion and may be attributed to the limitation of the infarct size, probably via A2-receptor-mediated coronary artery dilatation during the early period of reperfusions. Expand
Similarity and dissimilarity in mode and mechanism of action between YT-146, a selective adenosine receptor A2 agonist, and adenosine in isolated canine hearts.
TLDR
Although both YT-146 and adenosine produce an increase in coronary blood flow via adenoine A2 receptors, the opening of ATP- or glibenclamide-sensitive K channels is involved in the action of the former, but scarcely in theaction of the latter. Expand
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