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Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.
BACKGROUND & AIMS Increased inflammatory cytokine levels and intestinal epithelial cell apoptosis leading to disruption of epithelial integrity are major pathologic factors in inflammatory bowelExpand
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Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism.
Probiotics promote intestinal epithelial integrity and reduce infection and diarrhea. We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble proteins (p40 and p75) on the hydrogenExpand
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Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells*
  • F. Yan, D. Polk
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 27 December 2002
Probiotic bacteria are microorganisms that benefit the host by preventing or ameliorating disease. However, little information is known regarding the scientific rationale for using probiotics asExpand
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Systematic Review: Adverse Events of Fecal Microbiota Transplantation
Background Fecal microbiota transplantation (FMT) is a microbiota-based therapy that shows therapeutic potential in recurrent or refractory Clostridium difficile infections and other intestinal orExpand
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Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
  • F. Yan, H. Cao, +7 authors D. Polk
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1 June 2011
Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding of probiotic action is limited. We have identified a probioticExpand
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Regulation of apoptosis during homeostasis and disease in the intestinal epithelium.
A single epithelial layer serves as the interface between the organism and the contents of the gastrointestinal tract, underlining the importance of regulating cellular viability despite an onslaughtExpand
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Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice.
  • F. Yan, L. Wang, +10 authors D. Polk
  • Medicine
  • American journal of physiology. Gastrointestinal…
  • 1 March 2012
Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immune responses to microflora in genetically susceptible hosts. A major challenge for IBD research is to develop newExpand
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Activation of Peroxisome Proliferator-activated Receptor γ Suppresses Nuclear Factor κB-mediated Apoptosis Induced by Helicobacter pylori in Gastric Epithelial Cells*
Helicobacter pylori colonization leads to epithelial cell hyperproliferation within inflamed mucosa, but levels of apoptosis vary, suggesting that imbalances between rates of cell production and lossExpand
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Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.
BACKGROUND & AIMS Helicobacter pylori infection disrupts the balance between gastric epithelial cell proliferation and apoptosis, which is likely to lower the threshold for the development of gastricExpand
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Functional Analysis of the p40 and p75 Proteins from Lactobacillus casei BL23
The genomes of Lactobacillus casei/paracasei and Lactobacillus rhamnosus strains carry two genes encoding homologues of p40 and p75 from L. rhamnosus GG, two secreted proteins which displayExpand
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